218710

Casein Kinase II Inhibitor III, TBCA

The Casein Kinase II Inhibitor III, TBCA, also referenced under CAS 934358-00-6, controls the biological activity of Casein Kinase II. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• 동의어(들): Casein Kinase II Inhibitor III, TBCA, (E)-3-(2,3,4,5-Tetrabromophenyl)acrylic acid, CKII Inhibitor, TBCA
• 실험식(Hill 표기법): C₉H₄Br₄O₂
• CAS Number: 934358-00-6
• Molecular Weight: 463.74
• UNSPSC 코드: 12352200
• NACRES: NA.54

속성

• Quality Level: 100
• 분석: ≥95% (HPLC)
• 형태: solid
• 효능: 110 nM IC₅₀
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: off-white
• solubility: DMSO: 10 mg/mL (Use only fresh DMSO.); ethanol: 5 mg/mL
• 배송 상태: ambient
• 저장 온도: 2-8°C
• InChI: 1S/C9H4Br4O2/c10-5-3-4(1-2-6(14)15)7(11)9(13)8(5)12/h1-3H,(H,14,15)/b2-1+
• InChI key: SVJQCVOKYJWUBC-OWOJBTEDSA-N

설명

일반 설명

A cell-permeable tetrabrominated cinnamic acid compound that acts as a potent and ATP-competitive inhibitor of Casein Kinase II (IC₅₀ = 110 nM, K_i = 77 nM) with greater selectivity than TBB (Cat. Nos. 218697 and 218708) and DMAT (Cat. Nos. 218699 and 218706) against a panel of 28 commonly studied kinases. Shown to efficiently induces apoptosis in Jurkat cells (DC₅₀ = 7.7 µM). Also available as a 25 mM solution in DMSO (Cat. No. 218861).

A cell-permeable tetrabrominated cinnamic acid compound that acts as a potent and ATP-competitive inhibitor of Casein Kinase II (IC₅₀ = 110 nM, K_i = 77 nM) with greater selectivity than TBB (Cat. Nos. 218697 and 218708) and DMAT (Cat. Nos. 218699 and 218706) against a panel of 28 commonly studied kinases. Shown to efficiently induces apoptosis in Jurkat cells (DC₅₀ = 7.7 µM).

생화학적/생리학적 작용

Cell permeable: yes

Product competes with ATP.

Reversible: no

Target K_i: 77 nM against Casein Kinase II

포장

Packaged under inert gas

경고

Toxicity: Irritant (B)

기타 정보

Pagano, M.A., et al. 2006. Chembiochem8, 129

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H315,H319,H335
• 예방조치 성명서: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2