215900

Carbonic Anhydrase IX/XII Inhibitor

The Carbonic Anhydrase IX/XII Inhibitor controls the biological activity of Carbonic Anhydrase IX/XII. This small molecule/inhibitor is primarily used for Cancer applications.

• 동의어(들): Carbonic Anhydrase IX/XII Inhibitor, CAIX Inhibitor
• 실험식(Hill 표기법): C₁₃H₁₂N₄O₅S
• CAS Number: 175014-68-3
• Molecular Weight: 336.32
• MDL number: MFCD07097504
• UNSPSC 코드: 12352200
• NACRES: NA.54

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 형태: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: white
• solubility: DMSO: 50 mg/mL
• 배송 상태: ambient
• 저장 온도: 2-8°C
• SMILES string: O=C(NC1=CC=C(S(N)(=O)=O)C=C1)NC2=CC=C(N(=O)=O)C=C2

설명

일반 설명

A cell permeable benzenesulfonamide Carbonic Anhydrase (CA) inhibitor that is selective for human hCA IX and hCA XII (K_i = 0.9 nM and 5.7 nM, respectively) against two other physiologically relevant hCA isoforms (K_i = 23.4 nM and 15 nM for hCA I and hCA II, respectively), as compared with another CA inhibitor AAZ (K_i = 250 nM, 12 nM, 25 nM, and 5.7 nM for hCA I, hCA II, hCA IX, and hCA XII, respectively). It is shown to effectively inhibit the formation of metastases by 4T1 breast cancer cells in a mouse model dose-dependently at pharmacologic concentrations of 15-45 mg/kg.

A cell permeable benzenesulfonamide Carbonic Anhydrase (CA) inhibitor that is selective for human hCA IX and hCA XII (K_i = 0.9 nM and 5.7 nM, respectively) against two other physiologically relevant hCA isoforms (K_i = 23.4 nM and 15 nM for hCA I and hCA II, respectively), as compared with another CA inhibitor AAZ (K_i = 250 nM, 12 nM, 25 nM, and 5.7 nM for hCA I, hCA II, hCA IX, and hCA XII, respectively). It is shown to effectively inhibit the formation of metastases by 4T1 breast cancer cells in a mouse model dose-dependently at pharmacologic concentrations of 15-45 mg/kg.

포장

Packaged under inert gas

경고

Toxicity: Regulatory Review (Z)

기타 정보

Pacchiano, F., et al. 2011. J Med Chem.54, 1896.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable