208665

Calmidazolium Chloride

A cell-permeable calmodulin antagonist.

• 동의어(들): Calmidazolium Chloride, Compound R 24571
• 실험식(Hill 표기법): C₃₁H₂₃Cl₇N₂O
• CAS Number: 57265-65-3
• Molecular Weight: 687.70
• MDL number: MFCD00077679
• UNSPSC 코드: 12352200

속성

• Quality Level: 100
• 분석: ≥95% (HPLC)
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze
• 색상: white
• solubility: DMSO: 10 mg/mL; ethanol: 10 mg/mL
• 배송 상태: ambient
• 저장 온도: −20°C
• InChI: 1S/C31H24Cl6N2O.Cl/c32-23-6-1-20(2-7-23)31(21-3-8-24(33)9-4-21)39-14-13-38(19-39)17-30(27-12-11-26(35)16-29(27)37)40-18-22-5-10-25(34)15-28(22)36;/h1-16,30-31H,17-19H2;
• InChI key: LBFGPQFQXRJXDI-UHFFFAOYSA-N

설명

일반 설명

A cell-permeable calmodulin antagonist. An analog of sepazonium that is at least 150 times more potent than Trifluoperazine (Cat. No. 642150) as an inhibitor of brain Ca²⁺-calmodulin-dependent phosphodiesterase (IC₅₀ = 10 nM). Inhibits voltage-gated Ca²⁺ channels and stimulates the release of nitric oxide in neuroblastoma cells. Also, acts as a strong inhibitor of calcium-dependent Ca²⁺-ATPase in erythrocytes. Known to prolong cardiac refractory period in vivo.

A cell-permeable calmodulin antagonist. At least 150 times more potent than Trifluoperazine (Cat. No. 642150) as an inhibitor of brain calmodulin-dependent phosphodiesterase (IC₅₀ = 10 nM). An inhibitor of voltage-gated Ca²⁺ channels. Stimulates the release of nitric oxide in neuroblastoma cells. Also acts as a strong non-competitive inhibitor of skeletal muscle sarcoplasmic reticulum Ca²⁺-ATPase (K_i = 60 nM). Known to prolong cardiac refractoriness in vivo.

Note: easily adheres to glass in aqueous solution.

생화학적/생리학적 작용

Cell permeable: yes

Primary Target
brain calmodulin-dependent phosphodiesterase

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 10 nM against brain calmodulin-dependent phosphodiesterase

주의사항

readily adheres to glass in aqueous solution.

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short-term storage. DMSO stock solutions are stable for up to 2 months -20°C.

기타 정보

Hu, J., and El-Fakahany, E.E. 1993. NeuroReport. 4, 198.
Nakazawa, K., et al. 1993. Br. J. Pharmacol. 109, 137.
Yuasa, T., and Muto, S. 1992. Arch. Biochem. Biophys.296, 175.
Ichikawa, M., et al. 1991. J. Membrane Biol.120, 211.
Silver, P.J., et al. 1989. Cardiovasc. Drug Ther. 3, 675.
Anderson, K.W., et al. 1984. J. Biol. Chem.259, 11487.
Gietzen, L., et al. 1982. Biochem. J. 207, 541.
Van Belle, H. 1981. Cell Calcium2, 483.
Levin, R.N., and Weiss, B. 1979. J. Pharmacol. Exp. Therap.208, 454.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable