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모든 사진(1)

Key Documents

203980

Sigma-Aldrich

α-Bungarotoxin

from Bungarus multicinctus, No contaminants by IEF, lyophilized solid, irreversible binder to motor end-plate acetylcholine receptor, Calbiochem®

동의어(들):

α-Bungarotoxin, Bungarus multicinctus

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About This Item

실험식(Hill 표기법):
C338H529N97O105S11
CAS Number:
Molecular Weight:
7984.12
UNSPSC 코드:
12352200
NACRES:
NA.77

product name

α-Bungarotoxin, Bungarus multicinctus, Blocks neuromuscular transmission by irreversible binding to motor end-plate acetylcholine receptor (Kd = 1 pM to 1 nM) but does not depress acetylcholine release from motor nerve endings.

Quality Level

형태

lyophilized solid

제조업체/상표

Calbiochem®

저장 조건

OK to freeze

solubility

PBS: soluble
water: soluble

배송 상태

ambient

저장 온도

−20°C

일반 설명

A polypeptide composed of 74 amino acids containing 5 disulfide bridges. Blocks neuromuscular transmission by irreversible binding to the motor end-plate acetylcholine receptor (Kd = 1 nM to 1 pM) but does not depress acetylcholine release from motor nerve endings. Blocks nicotine-induced augmentation in intracellular Ca2+ in PC12 cells (IC50 = 310 nM). Prevents opening of nicotinic receptor-associated ion channels. Reconstitution experiments in Xenopus oocytes have shown the effects of α-Bungarotoxin on neuronal nAChR to be highly specific for the α7-subtype (IC50 = 1.6 nM), but not for the α3β4-subtype (IC50 >3 µM).
Blocks neuromuscular transmission by irreversible binding to motor end-plate acetylcholine receptor (Kd = 1 pM to 1 nM) but does not depress acetylcholine release from motor nerve endings. Blocks nicotine-induced increase of intracellular Ca2+ in PC12 cells (IC50 = 310 nM), and prevents opening of nicotinic receptor-associated ion channels. Reconstitution experiments in Xenopus oocytes have shown the effects of α-bungarotoxin on neuronal nAChR to be highly specific for the α7-subtype (IC50 = 1.6 nM), but not for the α3β4-subtype (IC50 >3 µM).

생화학적/생리학적 작용

Cell permeable: no
Kd = 1 pM to 1 nM for motor end-plate acetylcholine receptor
Primary Target
Motor end-plate acetylcholine receptor
Product does not compete with ATP.
Reversible: no

경고

Toxicity: Harmful (C)

서열

H-Ile-Val-Cys³-His-Thr-Thr-Ala-Thr-Ser-Pro-Ile-Ser-Ala-Val-Thr-Cys¹⁶-Pro-Pro-Gly-Glu-Asn-Leu-Cys²³-Tyr-Arg-Lys-Met-Trp-Cys²⁹-Asp-Ala-Phe-Cys³³-Ser-Ser-Arg-Gly-Lys-Val-Val-Glu-Leu-Gly-Cys⁴⁴-Ala-Ala-Thr-Cys⁴⁸-Pro-Ser-Lys-Lys-Pro-Tyr-Glu-Glu-Val-Thr-Cys⁵⁹-Cys⁶⁰-Ser-Thr-Asp-Lys-Cys⁶⁵-Asn-Pro-His-Pro-Lys-Gln-Arg-Pro-Gly-OH (disulfide bonds: 3 → 23; 16 → 44; 29 → 33; 48 → 59; 60 → 65)

물리적 형태

Supplied as an acetate salt

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

분석 메모

Contaminants: None detectable by IEF

기타 정보

Lopez, M.G., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 14184.
Zhang, Z.W., et al. 1994. Neuron 12, 167.
Bambrick, L.L., and Gordon, T. 1992. J. Physiol.449, 479.
Lin, S.R., and Chang, C.C. 1992. Biochim. Biophys. Acta1159, 255.
Motomura, M., et al. 1992. Neurosci. Lett.143, 139.
Sorenson, E.M., and Chiappinelli, V.A. 1992. J. Comp. Neurol.323, 1.
Ruan, K.H., et al. 1990. Proc. Natl. Acad. Sci. USA87, 6156.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


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