추천 제품
Quality Level
분석
≥90% (TLC)
형태
solid
반응 적합성
reagent type: chelator
제조업체/상표
Calbiochem®
저장 조건
OK to freeze
protect from light
색상
light yellow
solubility
DMSO: 10 mg/mL
배송 상태
ambient
저장 온도
−20°C
InChI
1S/C34H40N2O18/c1-23(37)47-19-51-31(41)15-35(16-32(42)52-20-48-24(2)38)27-9-5-7-11-29(27)45-13-14-46-30-12-8-6-10-28(30)36(17-33(43)53-21-49-25(3)39)18-34(44)54-22-50-26(4)40/h5-12H,13-22H2,1-4H3
InChI key
YJIYWYAMZFVECX-UHFFFAOYSA-N
일반 설명
Membrane-permeable form of BAPTA. Can be loaded into a wide variety of cells, where it is hydrolyzed by cytosolic esterases and is trapped intracellularly as the active chelator BAPTA. Prevents cocaine-induced ventricular fibrillations. Induces inactivation of protein kinase C. Also inhibits thapsigargin-induced apoptosis in rat thymocytes.
Membrane-permeable form of BAPTA. Can be loaded into a wide variety of cells, where it is hydrolyzed by cytosolic esterases and is trapped intracellularly as the active chelator BAPTA.Prevents cocaine-induced ventricular fibrillations. Abolishes vitamin D3-induced increase in intracellular Ca2+. Induces inactivation of protein kinase C. Also inhibits thapsigargin-induced apoptosis in rat thymocytes.
애플리케이션
- TRPV1-Dependent Antiproliferative Activity of Dioecious Maclura pomifera Extracts in Estrogen Receptor-Positive Breast Cancer Cell Lines Involves Multiple Apoptotic Pathways.: This study explores how BAPTA/AM, a calcium chelator, contributes to the antiproliferative effects by regulating TRPV1 and apoptotic pathways in breast cancer cells (Rumpa et al., 2024).
- Mitochondrial calcium uniporter promotes kidney aging in mice through inducing mitochondrial calcium-mediated renal tubular cell senescence.: The research highlights BAPTA/AM′s role in mitigating mitochondrial calcium overload, which is linked to cellular senescence and aging processes in renal cells (Xiong et al., 2024).
- TRPV3 facilitates lipolysis and attenuates diet-induced obesity via activation of the NRF2/FSP1 signaling axis.: This article discusses the role of BAPTA/AM in the modulation of TRPV3 channels, leading to enhanced lipolysis and protection against obesity through the NRF2/FSP1 pathway (Hu et al., 2024).
- Inflammation and Acinar Cell Dual-Targeting Nanomedicines for Synergistic Treatment of Acute Pancreatitis via Ca(2+) Homeostasis Regulation and Pancreas Autodigestion Inhibition.: BAPTA/AM is utilized to regulate calcium homeostasis, thereby preventing inflammation and autodigestion in acute pancreatitis treatments (Wang et al., 2024).
- IP(3)R-Mediated Calcium Release Promotes Ferroptotic Death in SH-SY5Y Neuroblastoma Cells.: This study investigates how BAPTA/AM inhibits IP3R-mediated calcium release, thereby reducing ferroptotic cell death in neuroblastoma cells (Campos et al., 2024).
포장
Packaged under inert gas
경고
Toxicity: Irritant (B)
재구성
Following reconstitution, aliquot, purge with inert gas and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
기타 정보
Bissonnette, M., et al. 1994. Am. J. Physiol.267, G465.
Jiang, S., et al. 1994. Exp. Cell Res.212, 84.
Billman, G.E. 1993. Am. J. Physiol. 265, H1529.
Dieter, P., et al. 1993. Biol. Chem. Hoppe Seyler 374, 171.
Harrison, S.M., and Bers, D.M. 1987. Biochim. Biophys. Acta 925, 133.
Harrison, S.M., and Bers, D.M. 1987. J. Biophys.51, 102A.
Marban, E., et al. 1986. J. Clin. Invest.78, 1185.
Tsien, R.Y. 1981. Nature290, 527.
Tsien, R.Y. 1980. Biochemistry19, 2396.
Jiang, S., et al. 1994. Exp. Cell Res.212, 84.
Billman, G.E. 1993. Am. J. Physiol. 265, H1529.
Dieter, P., et al. 1993. Biol. Chem. Hoppe Seyler 374, 171.
Harrison, S.M., and Bers, D.M. 1987. Biochim. Biophys. Acta 925, 133.
Harrison, S.M., and Bers, D.M. 1987. J. Biophys.51, 102A.
Marban, E., et al. 1986. J. Clin. Invest.78, 1185.
Tsien, R.Y. 1981. Nature290, 527.
Tsien, R.Y. 1980. Biochemistry19, 2396.
법적 정보
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
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