200484-M

Bestatin

Binds to cell surfaces and inhibits surface aminopeptidases, notably aminopeptidase B and leucine aminopeptidase.

• 동의어(들): Bestatin, [(2S,3R)-3-Amino-2-hydroxy-4-phenylbutanoyl]-Leu
• 실험식(Hill 표기법): C₁₆H₂₄N₂O₄
• CAS Number: 58970-76-6
• Molecular Weight: 308.37
• MDL number: MFCD00083262
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 설명: Merck USA index - 14, 9842
• 분석: >99% (HPLC)
• 양식: crystalline solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze
• 색상: white
• solubility: DMSO: 2 mg/mL; methanol: 5 mg/mL
• 저장 온도: 2-8°C
• SMILES string: [N+H3][C@@H]([C@H](O)C(=O)N[C@H](CC(C)C)C(=O)[O-])Cc1ccccc1
• InChI: 1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13-,14+/m1/s1
• InChI key: VGGGPCQERPFHOB-MCIONIFRSA-N

설명

일반 설명

Binds to cell surfaces and inhibits surface aminopeptidases, notably aminopeptidase B and leucine aminopeptidase. Also acts as a potent aminopeptidase N inhibitor. Activates macrophages and T lymphocytes. Has antitumor properties. Also available as a 50 mM solution in water (Cat. No. 200488).

생화학적/생리학적 작용

Primary Target
amino peptidase b

경고

Toxicity: Standard Handling (A)

제조 메모

Unstable in aqueous solution; dilute just prior to use.

재구성

Following reconstitution, aliquot and freeze (-20°C). DMSO and methanol stock solutions are stable for up to 1 month at -20°C.

기타 정보

Inoue, T., et al. 1994. J. Clin. Endocrinol. Metab. 79, 171.
Taylor, A., et al. 1993. Biochemistry32, 784.
Ishida, J.I., et al. 1984. J. Chromatogr.305, 381.
Umezawa, H. 1982. Annu. Rev. Microbiol.36, 75.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable