189485

Autocamtide-2 Related Inhibitory Peptide II, Cell-permeable

The Autocamtide-2 Related Inhibitory Peptide II, Cell-permeable controls the biological activity of calmodulin-dependent protein kinase II. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• 동의어(들): Autocamtide-2 Related Inhibitory Peptide II, Cell-permeable, Ant-A3K/V10F-AIP, Ant-AIP-II, Ac-RQIKIWFQNRRMKWKKKKKLRRQEAFDAL-OH
• 실험식(Hill 표기법): C₁₇₇H₂₉₁N₅₇O₃₉S
• Molecular Weight: 3873.63
• UNSPSC 코드: 12352202
• NACRES: NA.77

속성

• Quality Level: 200
• 분석: ≥97% (HPLC)
• 양식: lyophilized solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; desiccated (hygroscopic); protect from light
• 색상: white
• solubility: 5% acetic acid: 1 mg/mL; water: 1 mg/mL; DMSO: 5 mg/mL
• 배송 상태: wet ice
• 저장 온도: −20°C

설명

일반 설명

A highly specific, potent, cell-permeable calmodulin-dependent protein kinase II (CaMKII) inhibitor that contains the Antennapedia transport peptide sequence fused to the amino terminus of AIP-II (Cat. No. 189484).

A highly specific, potent, cell-permeable calmodulin-dependent protein kinase II (CaMKII) inhibitory peptide that contains the Antennapedia transport peptide sequence fused to the N-terminus of autocamtide inhibitory peptide-II (AIP-II) (Cat. No. 189484). AIP-II is an AIP analog where Ala³ and Val¹⁰ are replaced by Lys and Phe residues. AIP-II is reported to be more potent than CaMK-(281-302/Ala²⁸⁶) and KN-93 (Cat. No. 422708). Inhibits by binding to the autophosphorylation site, which is distinct from the exogenous substrate-binding site.

생화학적/생리학적 작용

Cell permeable: yes

Primary Target
cam Kinase-2

Product does not compete with ATP.

Reversible: no

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

서열

Ac-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Lys-Lys-Lys-Leu-Arg-Arg-Gln-Glu-Ala-Phe-Asp-Ala-Leu-OH

물리적 형태

Supplied as a trifluoroacetate salt.

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.

기타 정보

Watterson, D.M., et al. 2001. Neurochem. Int.39, 459.
Ishida, A., et al. 1998. FEBS Lett.427, 115.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable