182015

Cyclo(Arg-Gly-Asp-D-Phe-Val)

Potent inhibitor of cell adhesion.

• 동의어(들): Cyclo(Arg-Gly-Asp-D-Phe-Val), RGDFV Peptide, Cyclic
• 실험식(Hill 표기법): C₂₆H₃₈N₈O₇
• CAS Number: 137813-35-5
• Molecular Weight: 574.63
• UNSPSC 코드: 12352202
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥95% (HPLC)
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; desiccated (hygroscopic)
• 색상: white
• solubility: 1 N acetic acid: 5 mg/mL
• 배송 상태: ambient
• 저장 온도: −20°C

설명

일반 설명

Potent inhibitor of cell adhesion. Inhibits tumor cell adhesion to laminin and vitronectin substrates. In vivo investigations in rats showed it to be useful in the amelioration of ischemic acute renal failure in rats. Also inhibits tubular obstruction by preventing cell-cell adhesion. Inhibits the redistribution of c-Src into focal adhesions, thereby leading to impaired MAP Kinase activation.

Potent inhibitor of cell adhesion. Inhibits tumor cell adhesion to laminin and vitronectin substrates. In vivo investigations showed it to be useful in the amelioration of ischemic acute renal failure in rats. Also inhibits tubular obstruction by preventing cell-cell adhesion.

생화학적/생리학적 작용

Cell permeable: no

Primary Target
inhibits tumor cell adhesion to laminin and vitronectin substrates

Product does not compete with ATP.

Reversible: no

경고

Toxicity: Standard Handling (A)

기타 정보

Shono, T., et al. 2001. Exp. Cell Res.268, 169.
Matsuno, H., et al. 1994. Circulation 90, 2203.
Noiri, E., et al. 1994. Kidney Int. 46, 1050.
Gurrath, M., et al. 1992. Eur. J. Biochem. 210, 911.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable