178494

Apoptosis Inhibitor II, NS3694

The Apoptosis Inhibitor II, NS3694, also referenced under CAS 426834-38-0, controls the biological activity of Apoptosis. This small molecule/inhibitor is primarily used for Cancer applications.

• 동의어(들): Apoptosis Inhibitor II, NS3694, NS3694
• 실험식(Hill 표기법): C₁₅H₁₀ClF₃N₂O₃
• CAS Number: 426834-38-0
• Molecular Weight: 358.70
• MDL number: MFCD00249000
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥95% (HPLC)
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: white
• solubility: DMSO: 10 mg/mL; ethanol: slightly soluble
• 배송 상태: ambient
• 저장 온도: 2-8°C
• SMILES string: FC(F)(F)c1cc(ccc1)NC(=O)Nc2c(ccc(c2)Cl)C(=O)O
• InChI: 1S/C15H10ClF3N2O3/c16-9-4-5-11(13(22)23)12(7-9)21-14(24)20-10-3-1-2-8(6-10)15(17,18)19/h1-7H,(H,22,23)(H2,20,21,24)
• InChI key: GNCZTZCPXFDPLI-UHFFFAOYSA-N

설명

일반 설명

A cell-permeable diarylurea compound that specifically prevents the active ~700-kDa apoptosome complex formation triggered by cytochrome c release, thus blocking apoptosome-mediated caspase activation and cell death (50 µM completely blocks TNF-α-induced death in MCF-casp3 cells). Unlike M50054 (Cat. No. 178488), NS3694 exhibits no effect on apoptosome-independent caspase activation and cell death induced by FasL. Inhibits neither cytochrome c release nor the enzymatic activity of caspases.

A cell-permeable diarylurea compound that specifically prevents the formation of the active ~700 kDa apoptosome complex induced by cytochrome c release. Alters cytochrome c and ATP-triggered association between Apaf-1 and caspase-9. Protects against apoptosome-mediated caspase activation and cell death (50 µM completely blocks TNF-α-induced death in MCF-casp3 cells). Unlike M50054 (Cat. No. 178488), NS3694 exhibits no effect on apoptosome-independent caspase activation and cell death induced by Fas ligand (FasL). Does not inhibit cytochrome c release or the activity of caspase-3 and -9.

생화학적/생리학적 작용

Cell permeable: yes

Primary Target
Apoptosome complex formation

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 50 µM completely blocks TNF-α-induced death in MCF-casp3 cells

경고

Toxicity: Standard Handling (A)

기타 정보

Lademann, U., et al. 2003. Mol. Cell. Biol.23, 7829.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable