14-919-M

LRRK2 Protein, active, 10 µg

Active, N-terminal FLAG-tagged, recombinant, human LRRK2, amino acids 970-end. For use in Kinase Assays.

• UNSPSC 코드: 12352202
• eCl@ss: 32160405
• NACRES: NA.32

속성

• 생물학적 소스: human
• Quality Level: 100; 300
• 재조합: expressed in baculovirus infected Sf21 cells
• 분자량: M_w 180 kDa
• 제조업체/상표: Upstate^®
• 기술: activity assay: suitable (kinase)
• GenBank 수납 번호: BC117180
• UniProt 수납 번호: Q5S007
• 유전자 정보: human ... LRRK2(120892)

설명

일반 설명

Product Source: N-terminal FLAG-tagged, recombinant, human LRRK2 amino acids 970-end, expressed by baculovirus in Sf21 insect cells.

This protein is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8.

포장

Also available in 250μg size as catalog # 14-919M and in bulk as catalog # 14-919-K.

품질

Routinely evaluated by phosphorylation of ERMtide (RLGRDKYKTLRQIRQ)

물리적 형태

50mM Tris/HCl pH7.4, 300mM NaCl, 20mM β-glycerophosphate, 0.25mM sodium orthovanadate, 10mM NaF, 150µg/ml FLAG peptide, 20% v/v glycerol, 1mM benzamidine, 0.2mM PMSF, 5mM DTT. Frozen solution.

기타 정보

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

법적 정보

GenBank is a registered trademark of United States Department of Health and Human Services

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3