14-758-M

Ret (V804L) Protein, active, 10 µg

Active, N-Terminal GST-tagged, recombinant, human Ret amino acids 658 – end containing the V804L mutation. For use in Kinase Assays.

• UNSPSC 코드: 12352202
• eCl@ss: 32160405
• NACRES: NA.32

속성

• 생물학적 소스: human
• Quality Level: 100; 300
• 재조합: expressed in baculovirus infected Sf21 cells
• 분자량: M_w 79.2 kDa
• 제조업체/상표: Upstate^®
• 기술: activity assay: suitable (kinase)
• NCBI 수납 번호: NM_000323
• UniProt 수납 번호: P07949; P35546 (mouse)
• 유전자 정보: human ... RET(5979)

설명

일반 설명

N-Terminal GST-tagged, recombinant, human Ret amino acids 658 – end containing the V804L mutation.

Product Source: Expressed by baculovirus in Sf21 insect cells.

The V804L mutation has been identified in patients with familial medullary thyroid carcinoma (FMTC) (Lombardo F. et al., (2002), JCEM, 87, 1674-1680; Lesueur F. et al, (2005), JCEM, 90, 3454-3457).

애플리케이션

Research Category
Inflammation & Immunology

생화학적/생리학적 작용

Protein Target: Ret

Target Sub-Family: TK

포장

Also available in 250 µg size --call for pricing and availability and reference catalog number 14-758M when ordering the 250 µg size.

품질

Routinely evaluated by phosphorylation of CHKtide.

물리적 형태

50mM Tris-HCl pH7.5, 300mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 1mM benzamidine, 0.2mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution.

Glutathione agarose affinity chromatography

저장 및 안정성

Store -70°C. For maximum recovery of product, centrifuge original vial prior to removing the cap.
Rapidly thaw the vial under cold water and immediately place on ice. Aliquot unused material into pre-chilled microcentrifuge tubes and immediately snap-freeze the vials in liquid nitrogen prior to re-storage at -70°C.

기타 정보

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

법적 정보

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H317
• 예방조치 성명서: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Hazard Classifications: Skin Sens. 1
• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable