추천 제품
생물학적 소스
human
Quality Level
재조합
expressed in baculovirus infected Sf21 cells
제품 라인
Upstate®
특이 활성도
(For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.)
분자량
Mw 39.9 kDa
정제법
(Ni2+/NTA-agarose)
종 반응성
human
제조업체/상표
Upstate®
기술
activity assay: suitable (kinase)
수납 번호(accession number)
(FUNCTION: SwissProt: P52333 # Tyrosine kinase of the non-receptor type, involved in the interleukin-2 and interleukin-4 signaling pathway. Phosphorylates STAT6, IRS1, IRS2 and PI3K. )
NM_000215.2
NCBI 수납 번호
UniProt 수납 번호
일반 설명
N-terminal His6-tagged, recombinant, human JAK3 amino acids 781-end
애플리케이션
Research Category
Inflammation & Immunology
Inflammation & Immunology
생화학적/생리학적 작용
Protein Target: JAK3
Target Sub-Family: TK
포장
Also available in 10 μg size and in bulk
Also available in 250 µg size --call for pricing and availability and reference catalog number 14-629M when ordering the 250 µg size.
품질
routinely evaluated by phosphorylation of 500μM JAK3tide (Catalog # 12-547)
표적 설명
JAK3
물리적 형태
Ni2+/NTA-agarose
저장 및 안정성
6 months at -70°C
기타 정보
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
법적 정보
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
신호어
Warning
유해 및 위험 성명서
Hazard Classifications
Skin Sens. 1
Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 2
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
B A Witthuhn et al.
Nature, 370(6485), 153-157 (1994-07-14)
Many cytokines function through interaction with receptors of the cytokine receptor superfamily. Although lacking catalytic domains, cytokine receptors couple ligand binding to induction of protein tyrosine phosphorylation. Recent studies have shown that one or more of the Janus kinase family
J A Johnston et al.
Nature, 370(6485), 151-153 (1994-07-14)
Interleukin-2 is an autocrine growth factor for T cells which also activates other cells including B cells and natural killer cells. The subunits of the interleukin-2 receptor (IL-2R) lack intrinsic enzymatic activity, but protein tyrosine phosphorylation is a critical event
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