14-520-M

Casein Kinase 1δ (aa 1-294) Protein, active, 10 µg

Active, N-terminal, GST-tagged, recombinant human CK1 delta, amino acids 1-294, for use in Kinase Assays.

• 동의어(들): Kinase protein
• UNSPSC 코드: 12352202
• eCl@ss: 32160405
• NACRES: NA.32

속성

• 생물학적 소스: human
• Quality Level: 100
• 재조합: expressed in E. coli
• 분자량: M_w 61 kDa
• 제조업체/상표: Upstate^®
• 기술: activity assay: suitable (kinase)
• NCBI 수납 번호: NM_001893.3; NM_139062.1
• UniProt 수납 번호: P48730
• 유전자 정보: human ... CSNK1D(1453)

설명

일반 설명

Research area: Cell signaling

Research Category: Metabolism Research

Subcategory: Obesity

Protein Target: CK1γδ

Target Sub-Family: CK1

Casein Kinase 1δ (CK1δ ) is a serine/threonine kinase that belong to the family of casein kinase 1. The protein structure consists of anti-parallel β-sheet strands at N-terminal lobe (N-lobe) and α-helices and loop structures at the larger C-terminal lobe (C-lobe).

애플리케이션

Research Category
Metabolism

Research Sub Category
Obesity

Metabolic Disorders

생화학적/생리학적 작용

Casein Kinase 1δ (CK1δ) is implicated in multiple cellular processes, including membrane trafficking, cytokinesis, circadian rhythm, and tumorigenesis. It interacts with critical molecules within cancer-related signaling pathways, such as Wnt/β-catenin, PI3K/AKT, and Hedgehog. Therefore, mutations or overexpression of the CK1δ coding gene can potentially contribute to the onset and progression of cancer.

포장

Also available in 250 µg size --call for pricing and availability and reference catalog number 14-520M when ordering the 250 µg size.

품질

routinely evaluated by phosphorylation of KRRRALS(p)VASLPGL

물리적 형태

Glutathione-agarose

저장 및 안정성

6 months at -20°C

기타 정보

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

법적 정보

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H317
• 예방조치 성명서: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Hazard Classifications: Skin Sens. 1
• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2