14-439-M
MAP Kinase 1/Erk1 Protein, active, 10 µg
Active, recombinant, full-length, human MAP Kinase 1/Erk1 containing an N-terminal GST tag, for use in Kinase Assays.
동의어(들):
ERT1, Extracellular signal-regulated kinase 2 (ERK-2), MAPK 1, Mitogen-activated protein kinase 1, p44 MAPK
로그인조직 및 계약 가격 보기
모든 사진(2)
About This Item
UNSPSC 코드:
12352202
eCl@ss:
32160405
NACRES:
NA.32
추천 제품
생물학적 소스
human
Quality Level
재조합
expressed in E. coli
형태
liquid
분자량
Mw 69.9 kDa
제조업체/상표
Upstate®
기술
activity assay: suitable (kinase)
색상
colorless
solubility
water: soluble
NCBI 수납 번호
UniProt 수납 번호
유전자 정보
human ... MAPK3(5595)
일반 설명
Research area: Cell Signaling
Recombinant, full-length, human MAP Kinase 1/Erk1 containing an N-terminal GST tag
Recombinant, full-length, human MAP Kinase 1/Erk1 containing an N-terminal GST tag
생화학적/생리학적 작용
Extracellular-signal-regulated kinase 1 (ERK1)/ Extracellular-signal-regulated kinase 2 (ERK2), as part of the Ras-Raf-MEK-ERK signal transduction cascade, are involved in regulating a wide range of cellular processes, including cell adhesion, cell cycle progression, cell migration, cell survival, differentiation, metabolism, proliferation, and transcriptional control. Additionally, ERK1 signaling contributes to the regulation of cyclin D1 expression during the cell cycle. MAP kinases play a crucial role in inflammation and immune responses by regulating the production of pro- and anti-inflammatory cytokines, as well as prostaglandins, in response to lipopolysaccharide (LPS) stimulation.
포장
Also available in 250μg size as catalog # 14-439M - Call for pricing and availability.
품질
routinely evaluated by phosphorylation of MBP
물리적 형태
Purified by glutathione-agarose. Activated with MEK1 and repurified on Ni2+/NTA agarose
기타 정보
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
법적 정보
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
10 - Combustible liquids
WGK
WGK 2
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Y Zhang et al.
The Journal of biological chemistry, 276(24), 20913-20923 (2001-03-30)
Ultraviolet light A (UVA) plays an important role in the etiology of human skin cancer, and UVA-induced signal transduction has a critical role in UVA-induced skin carcinogenesis. The upstream signaling pathways leading to p70(S6K) phosphorylation and activation are not well
Lucinda F Reynolds et al.
The Journal of biological chemistry, 279(18), 18239-18246 (2004-02-07)
Vav1 is a signaling protein required for both positive and negative selection of CD4(+)CD8(+) double positive thymocytes. Activation of the ERK MAPK pathway is also required for positive selection. Previous work has shown that Vav1 transduces T cell receptor (TCR)
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