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Merck
모든 사진(1)

주요 문서

13-104

Sigma-Aldrich

MBP (myelin basic protein), bovine, purified

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About This Item

UNSPSC 코드:
12352202
eCl@ss:
32160405
NACRES:
NA.41

생물학적 소스

bovine

Quality Level

양식

liquid

유통기한

2 yr

제조업체/상표

Upstate®

기술

activity assay: suitable

solubility

water: soluble

UniProt 수납 번호

배송 상태

wet ice

저장 온도

−20°C

유전자 정보

bovine ... MBP(618684)

일반 설명

Myelin basic protein (MBP) belongs to the intrinsically disordered protein family. It is localized in the insulating layer of nerve cells in the brain and spinal cord. It is an abundant protein found in the central nervous system (CNS).
Research area: Cell Signaling
MBP is an alkaline protein with a pI of 11.6, constituting approximately 30% of the total protein content of the myelin in the central nervous system.

애플리케이션

MBP (myelin basic protein), bovine, purified has been used in western blotting and as a standard in enzyme-linked immunosorbent assay (ELISA).

생화학적/생리학적 작용

MBP can interact with various polyanionic proteins such as actin, tubulin, Ca2+-calmodulin, and clathrin, as well as negatively charged lipids. Upon binding to these proteins, MBP undergoes structural changes. It is believed to function as a membrane actin-binding protein, potentially enabling its involvement in relaying extracellular signals to the cytoskeleton in oligodendrocytes and tight junctions in myelin. External signals received by myelin or cultured oligodendrocytes lead to alterations in the phosphorylation of MBP, indicating its participation in signaling. The peptide MBP4-14 is specific for protein kinase C and is resistant to phosphatase activity. Moreover, MBP is extensively utilized in the "in gel" kinase assay, making it a vital biochemical for studying protein kinase activities.
Myelin basic protein (MBP), known as the ‘executive molecule of myelin′, helps in the formation of central nervous system (CNS) myelin. Elevated levels of MBP in the cerebrospinal fluid (CSF) are detected in acute neurological disorders like exacerbating multiple sclerosis, and traumatic brain injury. It is also observed at increased levels during chronic progressive disorders including dementia, tumor cerebri, and metabolic disorders. 

품질

routinely evaluated by successfully phosphorylating MAP Kinase 2/Erk2, active (Catalog # 14-173)

물리적 형태

10mM MOPS, pH 7.0, with 0.05% sodium azide

저장 및 안정성

2 years at -20°C

기타 정보

This product is derived from bovine source. Export of this product to certain countries may be restricted. Please contact Customer Service or your local distributor to inquire about product availability and export options.

법적 정보

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

12 - Non Combustible Liquids

WGK

nwg

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

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문서 라이브러리 방문

S L Sutor et al.
The Journal of biological chemistry, 274(11), 7002-7010 (1999-03-06)
Cytokines trigger the rapid assembly of multimolecular signaling complexes that direct the activation of downstream protein kinase cascades. Two protein kinases that have been linked to growth factor-regulated proliferation and survival are mitogen-activated protein/ERK kinase (MEK) and its downstream target
Discordant activation of stress-activated protein kinases or c-Jun NH2-terminal protein kinases in tissues of heat-stressed mice
Hu, Y., et al
The Journal of Biological Chemistry, 272, 9113-9119 (1997)
E E Gardiner et al.
The Journal of biological chemistry, 274(17), 11930-11936 (1999-04-17)
The interaction of fibrinogen (Fg) with intercellular adhesion molecule-1 (ICAM) on B-lymphoid Raji cells results in mitogenesis (Gardiner, E. E., and D'Souza, S. E. (1997) J. Biol. Chem. 272, 15474-15480). Incubation of Raji with Fg resulted in the increased tyrosine
A C Maroney et al.
The Journal of biological chemistry, 276(27), 25302-25308 (2001-04-28)
CEP-1347 (KT7515) promotes neuronal survival at dosages that inhibit activation of the c-Jun amino-terminal kinases (JNKs) in primary embryonic cultures and differentiated PC12 cells after trophic withdrawal and in mice treated with 1-methyl-4-phenyl tetrahydropyridine. In an effort to identify molecular
Ras-independent transformation by v-Src.
Aftab, D T, et al.
Proceedings of the National Academy of Sciences of the USA, 94, 3028-3033 (1997)

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