124038

Akt Inhibitor V, Triciribine

InSolution, ≥95%

• 동의어(들): InSolution Akt Inhibitor V, Triciribine
• 실험식(Hill 표기법): C₁₃H₁₆N₆O₄
• CAS Number: 35943-35-2
• Molecular Weight: 320.30
• MDL number: MFCD00932413
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥95% (HPLC)
• 양식: liquid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; avoid repeated freeze/thaw cycles; desiccated (hygroscopic); protect from light
• 배송 상태: ambient
• 저장 온도: −70°C
• SMILES string: [n]2(c3ncnc4c3c(c2)C(=N)NN4C)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)CO
• InChI: 1S/C13H16N6O4/c1-18-11-7-5(10(14)17-18)2-19(12(7)16-4-15-11)13-9(22)8(21)6(3-20)23-13/h2,4,6,8-9,13,20-22H,3H2,1H3,(H2,14,17)/t6-,8-,9-,13-/m1/s1
• InChI key: HOGVTUZUJGHKPL-HTVVRFAVSA-N

설명

일반 설명

A cell-permeable and reversible tricyclic nucleoside that selectively inhibits the cellular phosphorylation/activation of Akt1/2/3 by targeting an Akt effector molecule other than PI 3-K or PDK. Exhibits little effect towards cellular signaling pathways mediated by PKC, PKA, SGK, Stat3, p38, ERK1/2, or JNK. Shown to preferentially induce apoptosis and growth arrest in cancer cells with aberrant Akt activity both in vitro (≥60% in cell proliferation at 20 µM) and in vivo (≥80% inhibition in tumor growth in mice at 1 mg/kg/day, i.p.).

포장

Packaged under inert gas

경고

Toxicity: Irritant (B)

물리적 형태

A 2 mg/312 µl solution of Akt Inhibitor V, Triciribine (Cat. No. 124012) in DMSO.

재구성

Following intitial thaw, aliquot and freeze (-70°C).

기타 정보

Karst, A., et al. 2006. Cancer Res.66, 9225.
Yang, L., et al. 2004. Cancer Res.64, 4394.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point (°F): 188.6 °F - closed cup - (Dimethylsulfoxide)
• Flash Point (°C): 87 °C - closed cup - (Dimethylsulfoxide)