124005

Akt Inhibitor

The Akt Inhibitor controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• 동의어(들): Akt Inhibitor, 1L6-Hydroxymethyl-chiro-inositol-2-(R)-2-O-methyl-3-O-octadecyl- sn-glycerocarbonate, 1L6-Hydroxymethyl-chiro-inositol-2-(R)-2-O-methyl-3-O-octadecyl-sn-glycerocarbonate
• 실험식(Hill 표기법): C₃₀H₅₈O₁₀
• Molecular Weight: 578.78
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (NMR)
• 형태: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; desiccated (hygroscopic)
• 색상: white to off-white
• solubility: DMSO: 200 mg/mL
• 배송 상태: ambient
• 저장 온도: −20°C

설명

일반 설명

A cell permeable, reversible, and substrate competitive phosphatidylinositol ether analog that potently and selectively inhibits Akt (PKB) (IC₅₀ of 5.0 µM). Moderately inhibits PI 3-K activity (IC₅₀ = 83.0 µM). Also inhibits the growth of various cancer cell lines with IC₅₀ values in the 1 - 10 µM range.

A cell permeable, reversible, and substrate competitive phosphatidylinositol ether analog that potently and selectively inhibits Akt (PKB) (IC₅₀ of 5.0 µM). Moderately inhibits PI 3-K activity (IC₅₀ = 83.0 µM). Also inhibits the growth of various cancer cell lines with IC₅₀ values in the 1-10 µM range.

생화학적/생리학적 작용

Cell permeable: yes

Product competes with ATP.

Reversible: yes

Target IC₅₀: 5.0 µM for Akt (PKB)

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 weeks at -20°C.

Use anhydrous DMSO for reconstitution.

기타 정보

Hu, Y., et al. 2000 J. Med. Chem.43, 3045.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable