100073

15-PGDH Inhibitor

The 15-PGDH Inhibitor controls the biological activity of 15-PGDH. This small molecule/inhibitor is primarily used for Membrane applications.

• 동의어(들): 15-PGDH Inhibitor, 5-(4-(2-Cyclohexylethoxy)-3-methoxybenzylidene)thiazolidine-2,4-dione
• 실험식(Hill 표기법): C₁₉H₂₃NO₄S
• CAS Number: 1239610-60-6
• Molecular Weight: 361.46
• UNSPSC 코드: 51111800
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥99% (HPLC)
• 형태: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: yellow
• solubility: DMSO: 100 mg/mL, clear, pale yellow
• 배송 상태: ambient
• 저장 온도: 2-8°C
• SMILES string: O=C(NC/1=O)SC1=C/C2=CC=C(OCCC3CCCCC3)C(OC)=C2

설명

일반 설명

A cell-permeable, thiazolidinedione derivative that acts as a 15-hydroxyprostaglandin dehydrogenase (15-PGDH) inhibitor (IC₅₀ = 25 nM). It is shown to increase PGE2 levels in IL-1β-stimulated A549 cells, dose-dependently, in the range of 0–20 µM, and elicits cochlear blood flow (CBF) increase by 15% and 55% when applied intravenously to 250 g guinea pigs at 10 µg and 20 µg respectively.

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

기타 정보

Wu, Y., et al. 2011. J. Med. Chem.54, 5260.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable