07-2262

Anti-WNK3 Antibody

from rabbit, purified by affinity chromatography

• 동의어(들): WNK lysine deficient protein kinase 3, serine/threonine-protein kinase WNK3, Protein kinase with no lysine 3, Protein kinase lysine-deficient 3, protein kinase, lysine deficient 3
• UNSPSC 코드: 12352203
• eCl@ss: 32160702

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 정제법: affinity chromatography
• 종 반응성: human, mouse
• 기술: western blot: suitable
• NCBI 수납 번호: NP_001002838
• UniProt 수납 번호: Q9BYP7
• 배송 상태: wet ice
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... WNK3(65267)

설명

일반 설명

WNK3 is a serine-threonine protein kinase and expressed throughout the nephron, but most commonly at intercellular junctions. In its active state, it is a promoter of NKCC2 and NCC activity. The opposite is true of WNK3 when in an inactive state. WNK3 changes the expression of these transporters in the membrane and is thought to be a regulator of blood pressure along with other members of the WNK family of protein kinases. In recent research, WNK3 has also been linked to regulating signaling cascades involved in tumorigenesis.

특이성

Other homologies: Rat (74% sequence homology).

면역원

GST-tagged recombinant protein corresponding to human WNK3.

애플리케이션

Research Category
Signaling

Research Sub Category
Developmental Signaling

This WNK3 antibody is validated for use in WB for the detection of the WNK3 protein.

품질

Evaluated by Western Blot in HEK293 cell lysate.

Western Blot Analysis: 1:1,000 dilution of this antibody detected WNK3 on 10 µg of HEK293 cell lysate.

표적 설명

~220 kDa observed. Uncharacterized bands appear at ~52 and 60 kDa

물리적 형태

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

저장 및 안정성

Stable for 1 year at 2-8°C from date of receipt.

분석 메모

Control
HEK293 cell lysate

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable