05-23-3801

Endothelin 3, Human and Rat

Attenuates thrombin-evoked aggregation of human platelets.

• 동의어(들): Endothelin 3, Human and Rat, ET-3, CTCFTYKDKECVYYCHLDIIW
• 실험식(Hill 표기법): C₁₂₁H₁₆₈N₂₆O₃₃S₄
• CAS Number: 117399-93-6
• Molecular Weight: 2643.04
• MDL number: MFCD00076378
• UNSPSC 코드: 12352202
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥97% (HPLC)
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; desiccated
• solubility: 5% acetic acid: 0.5 mg/mL
• 배송 상태: ambient
• 저장 온도: −20°C
• InChI: 1S/C121H168N26O33S4/c1-11-62(7)97(117(175)139-89(121(179)180)49-70-53-126-77-25-17-16-24-75(70)77)145-118(176)98(63(8)12-2)144-112(170)88(52-95(157)158)136-105(163)81(44-60(3)4)131-109(167)86(50-71-54-125-59-127-71)134-113(171)90-56-182-181-55-76(124)101(
• InChI key: OQGZWNZGVYLIFX-XKIQDWPYSA-N

설명

일반 설명

Attenuates thrombin-evoked aggregation of human platelets. A potent stimulator of interleukin-6 production by endothelial cell lines. Reported to activate phospholipase C in fibroblasts expressing ET_A receptors.

생화학적/생리학적 작용

Cell permeable: no

Primary Target
Stimulator of interleukin-6 production by endothelial cell lines

Product does not compete with ATP.

Reversible: no

포장

Yes

서열

H-Cys¹-Thr-Cys³-Phe-Thr-Tyr-Lys-Asp-Lys-Glu-Cys¹¹-Val-Tyr-Tyr-Cys¹⁵-His-Leu-Asp-Ile-Ile-Trp-OH (disulfide bonds: 1 → 15; 3 → 11)

물리적 형태

Supplied as a trifluoroacetate salt. Sold on the basis of peptide content.

제조 메모

Dissolve peptide initially at 8 mg/ml in 80% cold acetic acid, then dilute with cold water to 5% acetic acid and 0.5 mg/ml peptide.

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

기타 정보

Gresser, O., et al. 1996. Biochem. Biophys. Res. Commun.224, 169.
Astarie-Dequeker, C., et al. 1995. Br. J. Pharmacol. 114, 524.
Xin, X., et al. 1995. Endocrinology 136, 132.
Brunner, F., et al. 1992. J. Mol. Cell. Cardiol.24, 1291.
Lamers, J.M., et al. 1992. Mol. Cell. Biochem. 116, 59.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable