04-1583

Anti-Interleukin 21 (IL-21) Antibody, clone 1G8

clone AB43.50.32H5.1G8, from mouse

• 동의어(들): interleukin 2, interleukin-2, interleukin-21 isoform
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: mouse
• Quality Level: 100
• 항체 형태: purified immunoglobulin
• 항체 생산 유형: primary antibodies
• 클론: AB43.50.32H5.1G8, monoclonal
• 종 반응성: human
• 기술: ELISA: suitable; western blot: suitable
• 동형: IgG2aκ
• NCBI 수납 번호: NP_068575
• UniProt 수납 번호: Q9HBE4
• 배송 상태: wet ice
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... IL21(59067)

설명

일반 설명

Interleukin 21 (IL-21) is a cytokine that has immunoregulatory activity on cells of the immune system, including natural killer (NK) cells and cytotoxic T cells that can destroy virally infected or cancerous cells. IL-21 induces cell division/proliferation in its target cells and is expressed in activated human CD4+ T cells. IL-21 may promote the transition between innate and adaptive immunity and may play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. IL-21 expression is up-regulated in Th2 and Th17 subsets of T helper cells, as well as follicular T cells. Furthermore IL-21 is expressed in NK T cells regulating the function of these cells. IL-21 is also produced by Hodgkin′s lymphoma (HL) cancer cells and may explain a great deal of the behavior of classical Hodgkin′s lymphoma including clusters of other immune cells gathered around HL cells in cultures.

면역원

Full length recombinant protein corresponding to human IL-21.

애플리케이션

ELISA Analysis: A previous lot was used by an independent laboratory in ELISA. (Dr. Gerard Zurawski, Baylor Institute for Immunology Research, Dallas, TX)

This Anti-Interleukin 21 (IL-21) Antibody, clone 1G8 is validated for use in WB, ELISA for the detection of Interleukin 21 (IL-21).

품질

Evaluated by Western Blot from human IL-21 recombinant protein.

Western Blot Analysis: 0.5 µg/mL of this antibody detected IL-21 on 10 µg of human IL-21 recombinant protein.

표적 설명

Two isoforms are observed at ~16 and ~18 kDa

물리적 형태

Format: Purified

분석 메모

Control
Human IL-21 recombinant protein

기타 정보

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable