H-105

17α-Hydroxypregnenolone solution

100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

• 실험식(Hill 표기법): C₂₁H₃₂O₃
• CAS Number: 387-79-1
• Molecular Weight: 332.48
• UNSPSC 코드: 41116107
• NACRES: NA.24

속성

• Grade: certified reference material
• 형태: liquid
• 특징: (Snap-N-Spike^®)
• 포장: ampule of 1 mL
• 제조업체/상표: Cerilliant^®
• 농도: 100 μg/mL in methanol
• 기술: gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• 응용 분야: clinical testing; clinical testing
• 형식: single component solution
• 저장 온도: −20°C
• InChI: 1S/C21H32O3/c1-13(22)21(24)11-8-18-16-5-4-14-12-15(23)6-9-19(14,2)17(16)7-10-20(18,21)3/h4,15-18,23-24H,5-12H2,1-3H3/t15-,16+,17-,18-,19-,20-,21-/m0/s1
• InChI key: JERGUCIJOXJXHF-TVWVXWENSA-N

설명

일반 설명

17α-Hydroxypregnenolone is a steroid hormone produced in the adrenal glands. This hormone is monitored as an ancillary test for congenital adrenal hyperplasia (CAH), particularly in situations where diagnosis of 21-hydroxylase and 11-hydroxylase eficiency has been ruled out. This Certified Spiking Solution^® is suitable for use as starting material in linearity standards, calibrators, and controls fo numerous LC-MS/MS applications in endocrinology, clinical chemistry, and neonatal screening.

애플리케이션

• Enhancement of Steroidogenic Enzyme Assays: The role of protein-protein and protein-membrane interactions in cytochrome P450 function, which is crucial for understanding the enzymatic activities involved in steroid biosynthesis, including those mediated by 17 alpha-Hydroxypregnenolone (Scott EE et al., 2016).


• Modeling Steroid Hormone Biosynthesis: Research explores how ligand and cytochrome b5 modulate the conformation of human cytochrome P450 17A1, a key enzyme in the biosynthesis of neurosteroids from precursors like 17 alpha-Hydroxypregnenolone, providing insights for biochemical steroidogenesis research (Estrada DF et al., 2014).


• Development of ELISA for Steroid Detection: The study demonstrate the covalent coupling of steroids to microwell plates, facilitating the use of 17 alpha-Hydroxypregnenolone in competitive enzyme-linked immunosorbent assays (ELISA) for steroid hormone precursor detection and quantification in biochemical assays (Yonezawa S et al., 1993).

법적 정보

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• 픽토그램: GHS02,GHS06,GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H225,H301 + H311 + H331,H370
• 예방조치 성명서: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• 표적 기관: Eyes
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 1
• Flash Point (°F): 49.5 °F - closed cup
• Flash Point (°C): 9.7 °C - closed cup