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Key Documents

880680P

Avanti

C16 PEG750 Ceramide

Avanti Research - A Croda Brand 880680P, powder

동의어(들):

N-palmitoyl-sphingosine-1-{succinyl[methoxy(polyethylene glycol)750]}

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About This Item

CAS Number:
UNSPSC 코드:
12352211
NACRES:
NA.25

형태

powder

포장

pkg of 1 × 25 mg (880680P-25mg)

제조업체/상표

Avanti Research - A Croda Brand 880680P

배송 상태

dry ice

저장 온도

−20°C

SMILES string

O=C(CCC(OC[C@]([H])(NC(CCCCCCCCCCCCCCC)=O)[C@]([H])(O)/C=C/CCCCCCCCCCCCC)=O)OOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC.C=C

일반 설명

Ceramide is a sphingolipid metabolite. The ceramides differ in their acyl chain length.

애플리케이션

C16 PEG750 Ceramide might be used as a control to test for nonspecific interactions during titrations of DNA-nanotube complexes with polyethylene glycol (PEG)-conjugated lipids.

생화학적/생리학적 작용

Therapeutic drugs enclosed in poly-ethylene glycol (PEG) conjugated ceramide serves as liposomal carriers, ensuring a longer circulation period. It exhibits a neutral surface electrostatic charge which prevents the leaking of positively charged encapsulated drug molecule.

포장

5 mL Amber Glass Screw Cap Vial (880680P-25mg)

법적 정보

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3


시험 성적서(COA)

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문서 라이브러리 방문

Prakrit V Jena et al.
ACS nano, 11(11), 10689-10703 (2017-09-13)
Lipid accumulation within the lumen of endolysosomal vesicles is observed in various pathologies including atherosclerosis, liver disease, neurological disorders, lysosomal storage disorders, and cancer. Current methods cannot measure lipid flux specifically within the lysosomal lumen of live cells. We developed
M S Webb et al.
Biochimica et biophysica acta, 1372(2), 272-282 (1998-07-24)
Poly(ethylene glycol) (PEG) conjugated lipids have been used to increase the circulation longevity of liposomal carriers encapsulating therapeutic compounds. PEG is typically conjugated to distearoylphosphatidylethanolamine (DSPE) via a carbamate linkage that results in a net negative charge on the phosphate
Jamie L Betker et al.
Journal of pharmaceutical sciences (2020-02-01)
Nanoparticle-mediated drug delivery has long utilized PEGylation as a mechanism for reducing uptake by the reticuloendothelial system and extending circulation lifetimes. However, studies over the past 2 decades have established that immune responses to PEG can promote clearance on repeat injection

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