추천 제품
형태
powder
포장
pkg of 1 × 1 mg (867000P-1mg)
제조업체/상표
Avanti Research™ - A Croda Brand
지질 유형
sphingolipids
배송 상태
dry ice
저장 온도
−20°C
SMILES string
O[C@]([H])(CCCCCCCCCCCCCC)[C@](O)([H])[C@@]([H])(NC(CCCCCCCCCCCCCCCCCCCCCCCCC)=O)CO[C@@H](O1)[C@H](O)[C@@H](O)[C@H]([C@H]1CO)O
InChI
1S/C50H99NO9/c1-3-5-7-9-11-13-15-17-18-19-20-21-22-23-24-25-26-27-29-31-33-35-37-39-45(54)51-42(41-59-50-49(58)48(57)47(56)44(40-52)60-50)46(55)43(53)38-36-34-32-30-28-16-14-12-10-8-6-4-2/h42-44,46-50,52-53,55-58H,3-41H2,1-2H3,(H,51,54)/t42?,43-,44-,46+,47+,48+,49-,50+/m1/s1
InChI key
VQFKFAKEUMHBLV-VDYNBUGPSA-N
일반 설명
α-Galactosyl Ceramide (KRN7000) is a high affinity glycolipid ligand for invariant natural killer T cell (iNKT). It has α-galactosyl ceramide core and is a variant of agelasphin-9b ceramide core. It is a synthetic homolog of α‐GalCer from marine sponges. It comprises long fatty acyl chain (C26) and sphingosine base (C18).
애플리케이션
α-Galactosyl Ceramide (KRN7000) has been used in the in-vitro stimulation of natural killer cells. It is suitable for use as a lipid antigen in bone marrow derived cells (BMDC) and hepatocyte primary cells prior to antigen presentation assay. It is also suitable for use as a ligand invariant natural killer T cell activation.
생화학적/생리학적 작용
α-Galactosyl Ceramide (KRN7000) administration results in T helper (TH0) or TH2 cytokine response. it displays potent antitumor activity in various in vivo models such as B6 melanoma, colon26 adenocarcinoma and hepatic metastases.
포장
5 mL Amber Glass Screw Cap Vial (867000P-1mg)
기타 정보
Not available in Japan
법적 정보
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Antitumor effect of alpha-galactosylceramide (KRN7000) on spontaneous hepatic metastases requires endogenous interleukin 12 in the liver
Fuji N, et al.
Clinical Cancer Research, 6(8), 3380-3387 (2000)
Pivotal Advance: alpha-Galactosylceramide induces protection against lipopolysaccharide-induced shock
Sireci G, et al.
Journal of Leukocyte Biology, 81(3), 607-622 (2007)
N Fuji et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 6(8), 3380-3387 (2000-08-24)
Hepatic metastasis is a major clinical problem in cancer treatment. We examined antitumor activity of alpha-galactosylceramide (KRN7000) on mice with spontaneous liver metastases of reticulum cell sarcoma M5076 tumor cells (spontaneous metastasis model). In this model, all mice that were
Synthesis and Biological Activities of 5-Thio-alpha-GalCers
Bi J, et al.
ACS Medicinal Chemistry Letters, 6(4), 476-480 (2015)
TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival
Zhu L, et al.
Nature Communications, 9(1), 2812-2812 (2018)
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