추천 제품
양식
powder
포장
pkg of 1 × 25 mg (860569P-25mg)
pkg of 1 × 5 mg (860569P-5mg)
제조업체/상표
Avanti Research™ - A Croda Brand 860569P
지질 유형
sphingolipids
배송 상태
dry ice
저장 온도
−20°C
SMILES string
[H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@@]([H])(NC(CCCCCCCCCCCCCCCC)=O)CO[C@H](O1)[C@H](O)[C@@H](O)[C@@H]([C@H]1CO)O
일반 설명
Glucosyl(β) Ceramide (β-GlcCer) is a naturally occurring glycolipid. It is also a ubiquitous intracellular metabolite.
생화학적/생리학적 작용
Glucosyl(β) Ceramide (β-GlcCer) regulates the activity of natural killer T (NKT) lymphocytes and displays antimetastatic effects. It is an endogenous macrophage inducible C-type lectin (Mincle) ligand, which exhibits immunostimulatory property. β-GlcCer promotes inflammatory and acquired immune responses on myeloid cells via Mincle. It acts as a potential biomarker for Gaucher′s disease.
포장
5 mL Amber Glass Screw Cap Vial (860569P-25mg)
5 mL Amber Glass Screw Cap Vial (860569P-5mg)
법적 정보
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class Code
11 - Combustible Solids
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이미 열람한 고객
Masashi Inafuku et al.
Lipids, 47(6), 581-591 (2012-03-20)
Natural killer (NK) T cells are well known to play important roles in both tumor rejection and the defense against infectious. Therefore, the antitumor potential of NKT cell-activating antigens have been the focus for the development of NKT cell-based immunotherapies.
E Zigmond et al.
Gut, 56(1), 82-89 (2006-12-19)
beta-Glucosylceramide, a naturally occurring glycolipid, exerts modulatory effects on natural killer T (NKT) lymphocytes. To determine whether beta-glucosylceramide can alter NKT function in opposite directions, colitis was induced by intracolonic installation of trinitrobenzenesulphonic acid, and hepatocellular carcinoma (HCC) was induced
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