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Merck
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857395P

Avanti

GT-11

N-[(1R,2S)-2-hydroxy-1-hydroxymethyl-2-(2-tridecyl-1-cyclopropenyl)ethyl]octanamide, powder

동의어(들):

C8-CPPC, C8-cyclopropenylceramide, GT-11 dihydroceramide desaturase inhibitor

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모든 사진(2)

About This Item

실험식(Hill 표기법):
C28H53NO3
CAS Number:
649767-83-9
Molecular Weight:
451.73
UNSPSC 코드:
12352211
NACRES:
NA.25

분석

>99% (TLC)

양식

powder

포장

pkg of 1 × 1 mg (857395P-1mg)

제조업체/상표

Avanti Research™ - A Croda Brand 857395P

지질 유형

bioactive lipids
sphingolipids

배송 상태

dry ice

저장 온도

−20°C

SMILES string

CCCCCCCCCCCCCCC1=C(C1)[C@@H](O)[C@@H](NC(CCCCCCC)=O)CO

InChI

1S/C28H53NO3/c1-3-5-7-9-10-11-12-13-14-15-17-18-20-24-22-25(24)28(32)26(23-30)29-27(31)21-19-16-8-6-4-2/h26,28,30,32H,3-23H2,1-2H3,(H,29,31)/t26-,28+/m0/s1

InChI key

AQFQOEPCXZMMDT-XTEPFMGCSA-N

일반 설명

GT-11 is also termed as C8-cyclopropenylceramide or C8-CPPC.

생화학적/생리학적 작용

GT-11 is an inhibitor of dihydroceramides (DHCer) desaturase activity.

포장

5 mL Amber Glass Screw Cap Vial (857395P-1mg)

법적 정보

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

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시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리 방문

Inhibition of sphingolipid metabolism enhances resveratrol chemotherapy in human gastric cancer cells
Shin K, et al.
Biomolecules & Therapeutics, 20(5), 470-470 (2012)
Gemma Triola et al.
Molecular pharmacology, 66(6), 1671-1678 (2004-09-17)
Dihydroceramide desaturase catalyzes the conversion of the innocuous precursor dihydroceramide into a highly bioactive product ceramide. We studied the effect of N-[(1R,2S)-2-hydroxy-1-hydroxymethyl-2-(2-tridecyl-1-cyclopropenyl)ethyl]octanamide (GT11), the first inhibitor of this enzyme, in primary cultured cerebellar neurons. Although desaturase was efficiently inhibited (IC50
Bioactive sphingolipids: An overview on ceramide, ceramide 1-phosphate dihydroceramide, sphingosine, sphingosine 1-phosphate
Handbook of Neurochemistry and Molecular Neurobiology:Neural Lipids, 373-383 (2010)
Pau Muñoz-Guardiola et al.
Autophagy, 17(6), 1349-1366 (2020-05-14)
ABTL0812 is a first-in-class small molecule with anti-cancer activity, which is currently in clinical evaluation in a phase 2 trial in patients with advanced endometrial and squamous non-small cell lung carcinoma (NCT03366480). Previously, we showed that ABTL0812 induces TRIB3 pseudokinase

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