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857390P

Avanti

W146

(R)-3-Amino-(3-hexylphenylamino)-4-oxobutylphosphonic acid (TFA salt), powder

동의어(들):

S1P1 Antagonist

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모든 사진(2)

About This Item

실험식(Hill 표기법):
C18H28F3N2O6P
CAS Number:
909725-62-8
Molecular Weight:
456.39
UNSPSC 코드:
12352211
NACRES:
NA.25

분석

>99% (TLC)

형태

powder

포장

pkg of 1 × 1 mg (857390P-1mg)
pkg of 1 × 10 mg (857390P-10mg)

제조업체/상표

Avanti Research™ - A Croda Brand 857390P

지질 유형

sphingolipids

배송 상태

dry ice

저장 온도

−20°C

일반 설명

Compound 2a is a selective antagonist for human S1P1 (hS1P1) receptor activation by the physiological agonist S1P.
W146 is a sphingosine-1-phosphate 1 (S1P1) selective antagonist.

애플리케이션

W146 has been used:
  • to verify the mode of action of sphingosine-1-phosphate (S1P) in human bone marrow derived mesenchymal stem cells (hMSCs ) and primary human hepatogenic profibrotic cells (hHPCs)
  • to study oxidative stress and drug treatment in granulosa cells
  • to evaluate its effects on transendothelial electrical resistance (TEER)

생화학적/생리학적 작용

W146 acts as an orthosteric antagonist. It is linked to blood lymphopenia and lung edema in mice.

포장

5 mL Amber Glass Screw Cap Vial (857390P-10mg)
5 mL Amber Glass Screw Cap Vial (857390P-1mg)

법적 정보

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

No data available

Flash Point (°C)

No data available

시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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문서 라이브러리 방문

Sphingosine-1-phosphate inhibits H2O2-induced granulosa cell apoptosis via the PI3K/Akt signaling pathway
Nakahara T, et al.
Fertility and Sterility, 98(4) (2012)
Kelley M Argraves et al.
The Journal of biological chemistry, 283(36), 25074-25081 (2008-07-09)
High density lipoproteins (HDL) are major plasma carriers of sphingosine 1-phosphate (S1P). Here we show that HDL increases endothelial barrier integrity as measured by electric cell substrate impedance sensing. S1P was implicated as the mediator in this process through findings
S1P, dihydro-S1P and C24: 1-ceramide levels in the HDL-containing fraction of serum inversely correlate with occurrence of ischemic heart disease
Argraves KM, et al.
Lipids in Health and Disease, 10(1), 70-70 (2011)
The sphingosine-1-phosphate receptor-1 antagonist, W146, causes early and short-lasting peripheral blood lymphopenia in mice
Tarrason G, et al.
International Immunopharmacology, 11(11), 1773-1779 (2011)
The sphingosine-1-phosphate receptor-1 antagonist, W146, causes early and short-lasting peripheral blood lymphopenia in mice
Sphingosine-1-Phosphate Signaling in Immunology and Infectious Diseases (2014)
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