810174P
Avanti
16:0-12:0 NBD PA
Avanti Polar Lipids 810174P, powder
동의어(들):
1-palmitoyl-2-{12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl}-sn-glycero-3-phosphate (ammonium salt)
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모든 사진(2)
About This Item
실험식(Hill 표기법):
C37H66N5O11P
CAS Number:
Molecular Weight:
787.92
UNSPSC 코드:
12352211
NACRES:
NA.25
추천 제품
분석
>99% (TLC)
형태
powder
포장
pkg of 1 × 1 mg (810174P-1mg)
제조업체/상표
Avanti Polar Lipids 810174P
배송 상태
dry ice
저장 온도
−20°C
일반 설명
Phosphatidic acid (PA) is a simple anionic cellular glycerophospholipid possessing a phosphomonoester polar head group and two long hydrophobic acyl chains. 7-nitro-2-1,3-benzoxadiazol-4-yl (NBD) PA is a fluorophore labeled phospholipid having 7-nitrobenz-2-oxa-1,3-diazol-4-yl (NBD) at the sn-2 fatty acid of PA.
애플리케이션
16:0-12:0 NBD PA or 1-palmitoyl-2-{12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl}-sn-glycero-3-phosphate (ammonium salt) is suitable:
- to incubate cells for the imaging of lyso phosphatidylcholine (PC) in P. falciparum live cells
- as a component of separation buffer for the separation of phosphoinositides and sphingolipids in the microchip devices
- in cytidine diphosphate diacylglycerol (CDP-DAG) synthase activity assay
생화학적/생리학적 작용
Phosphatidic acid (PA) influences membrane fusion and membrane fission events and membrane curvature. It acts as a signaling molecule for various cellular processes including membrane trafficking and sperm hyper-activation.
포장
5 mL Amber Glass Screw Cap Vial (810174P-1mg)
법적 정보
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class Code
11 - Combustible Solids
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Yasushi Tamura et al.
Cell metabolism, 17(5), 709-718 (2013-04-30)
CDP-diacylglycerol (CDP-DAG) is central to the phospholipid biosynthesis pathways in cells. A prevailing view is that only one CDP-DAG synthase named Cds1 is present in both the endoplasmic reticulum (ER) and mitochondrial inner membrane (IM) and mediates generation of CDP-DAG
Tam41 is a CDP-diacylglycerol synthase required for cardiolipin biosynthesis in mitochondria
Tamura Y, et al.
Cell Metabolism, 17(5), 709-718 (2013)
Phosphatidic acid binding proteins display differential binding as a function of membrane curvature stress and chemical properties
Putta P, et al.
Biochimica et Biophysica Acta, 1858(11), 2709-2716 (2016)
Phosphatidic acid in membrane rearrangements
Zhukovsky MA, et al.
Febs Letters, 593(17), 2428-2451 (2019)
Mikhail A Zhukovsky et al.
FEBS letters, 593(17), 2428-2451 (2019-08-01)
Phosphatidic acid (PA) is the simplest cellular glycerophospholipid characterized by unique biophysical properties: a small headgroup; negative charge; and a phosphomonoester group. Upon interaction with lysine or arginine, PA charge increases from -1 to -2 and this change stabilizes protein-lipid
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