추천 제품
분석
>99% (TLC)
양식
methylene chloride solution
포장
pkg of 1 × 1 mL (700184M-1mg)
제조업체/상표
Avanti Research™ - A Croda Brand 700184M
농도
1 mg/mL (700184M-1mg)
배송 상태
dry ice
저장 온도
−20°C
일반 설명
Desmosterol is a precursor of cholesterol synthesis and the enzyme 24-dehydrocholesterol reductase catalyzes this step. It lacks a double bond between C24 and C25, which is present in cholesterol. Desmosterol is the major brain sterol and is localized in spermatozoa membrane and astrocytes. Desmosterol (D6) ester is a deuterated desmosterol with octadecanoic acid.
생화학적/생리학적 작용
Desmosterol is a liver X receptor (LXR) agonist and it regulates inflammatory signaling in macrophages. Desmosterol accumulates during impairment of 24-dehydrocholesterol reductase enzyme thereby leading to desmosterolosis. It is a potential therapeutic target for treating the neurodegenerative disorder.
포장
5 mL Clear Glass Sealed Ampule (700184M-1mg)
법적 정보
Avanti Research is a trademark of Avanti Polar Lipids, LLC
신호어
Warning
유해 및 위험 성명서
Hazard Classifications
Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
표적 기관
Central nervous system
WGK
WGK 2
가장 최신 버전 중 하나를 선택하세요:
Saara Vainio et al.
The Journal of biological chemistry, 281(1), 348-355 (2005-10-27)
Desmosterol is an immediate precursor of cholesterol in the Bloch pathway of sterol synthesis and an abundant membrane lipid in specific cell types. The significance of the difference between the two sterols, an additional double bond at position C24 in
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