추천 제품
양식
powder
포장
pkg of 1 × 1 mg (700138P-1mg)
제조업체/상표
Avanti Research™ - A Croda Brand 700138P
배송 상태
dry ice
저장 온도
−70°C
InChI
1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9-10,19,21,23-25,28H,6,8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1
InChI key
RUSSPKPUXDSHNC-DDPQNLDTSA-N
일반 설명
7-dehydrodesmosterol (7-DHD) is synthesized via the Bloch pathway. 7-DHD serves as a desmosterol synthesis precursor and the enzyme 7-dehydrocholesterol reductase (DHCR7) catalyzes this step.
애플리케이션
7-dehydrodesmosterol has been used as an internal oxysterol standard in ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS).
생화학적/생리학적 작용
7-dehydrodesmosterol (7-DHD) levels are higher during fetal development and increases with aging. Elevated levels of 7-DHD is associated with Smith-Lemli-Opitz syndrome mouse model. Reduced levels of 7-DHD is observed in shiverer and quaking disorder.
포장
5 mL Amber Glass Screw Cap Vial (700138P-1mg)
법적 정보
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class Code
11 - Combustible Solids
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이미 열람한 고객
J M Bourre et al.
Journal of neurochemistry, 54(4), 1196-1199 (1990-04-01)
In rat sciatic nerve, the 7-dehydrocholesterol content decreased dramatically during the postnatal period and slowly during adulthood and aging. In contrast, the 7-dehydrodesmosterol content peaked at 14 days and was nearly undetectable after 60 days. The desmosterol content peaked at
Josi Herron et al.
Current protocols in toxicology, 78(1), e65-e65 (2018-10-16)
Cholesterol and cholesterol-derived oxysterols are critical for embryonic development, synapse formation and function, and myelination, among other biological functions. Indeed, alterations in levels of cholesterol, sterol precursors, and oxysterols result in a variety of developmental disorders, emphasizing the importance of
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