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Merck
모든 사진(1)

주요 문서

700127P

Avanti

7-keto-25-hydroxycholesterol

3β,25-dihydroxy-5-cholesten-7-one, powder

동의어(들):

cholest-5-ene-7-one-3β,25-diol

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모든 사진(1)

About This Item

실험식(Hill 표기법):
C27H44O3
CAS Number:
64907-23-9
Molecular Weight:
416.64
MDL number:
MFCD01310734
UNSPSC 코드:
12352211
NACRES:
NA.25

분석

>99% (TLC)

양식

powder

포장

pkg of 1 × 1 mg (700127P-1mg)
pkg of 1 × 5 mg (700127P-5mg)

제조업체/상표

Avanti Research™ - A Croda Brand 700127P

배송 상태

dry ice

저장 온도

−20°C

일반 설명

7-keto-25-hydroxycholesterol synthesis from 7-ketocholesterol is catalyzed by the enzyme cholesterol 25-hydroxylase. 7β,25-dihydroxycholesterol (7β25OHC) is produced from the stereospecific reduction of 7k25OHC by the action of enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). 11β-HSD type 2 enzyme catalyzes the reverse conversion of 7β25OHC to 7k25OHC.

애플리케이션

7-keto-25-hydroxycholesterol has been used as a substrate for 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) expressed in human embryonic kidney (HEK)-293 cells to test the oxoreduction functionality of the enzyme. It has also been used to test its effect on Epstein-Barr virus-induced seven-transmembrane receptor (EB12) activation.

생화학적/생리학적 작용

7-keto-25-hydroxycholesterol (7k25OHC) might interact with the cysteine-rich domain (CRD) of the smoothened (Smo) in the hedgehog pathway. However, 7-keto-25-OHC is incapable of activating Smo.

포장

5 mL Amber Glass Screw Cap Vial (700127P-1mg)
5 mL Amber Glass Screw Cap Vial (700127P-5mg)

법적 정보

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

No data available

Flash Point (°C)

No data available

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시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리 방문

Pengxiang Huang et al.
Cell, 166(5), 1176-1187 (2016-08-23)
In vertebrates, sterols are necessary for Hedgehog signaling, a pathway critical in embryogenesis and cancer. Sterols activate the membrane protein Smoothened by binding its extracellular, cysteine-rich domain (CRD). Major unanswered questions concern the nature of the endogenous, activating sterol and the
Katharina R Beck et al.
The Journal of steroid biochemistry and molecular biology, 190, 19-28 (2019-03-25)
Oxysterols are cholesterol metabolites derived through either autoxidation or enzymatic processes. They consist of a large family of bioactive lipids that have been associated with the progression of multiple pathologies. In order to unravel (patho-)physiological mechanisms involving oxysterols, it is

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