QBD10199

dPEG^®₄-biotin acid

>95% (HPLC)

• 동의어(들): Biotin-PEG-acid, Biotin-PEG₄-COOH, Biotin-PEG₄-acid, Carboxy-PEG₄-biotin, PEG₄-biotin acid
• 실험식(Hill 표기법): C₂₁H₃₇N₃O₈S
• Molecular Weight: 491.60
• UNSPSC 코드: 12352106
• NACRES: NA.22

속성

• 분석: >95% (HPLC)
• 양식: solid or viscous liquid
• 반응 적합성: reaction type: Biotinylations; reaction type: Pegylations
• 폴리머 구조: shape: linear; functionality: monofunctional
• 배송 상태: ambient
• 저장 온도: −20°C

설명

특징 및 장점

dPEG₄ biotin acid consists of biotin and a propionic acid-functionalized tetraethylene glycol derivative. Numerous functional or reactive groups can modify the terminal acid moiety, including the acylating agents N-hydroxysuccinimide (NHS) and 2,3,5,6-tetrafluorophenol (TFP). Also, dPEG4 biotin acid reacts directly with primary amines using a suitable carbodiimide such as 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC). The amphiphilic dPEG linker gives biotin excellent solubility in water and aqueous buffer, where biotin usually is poorly soluble. dPEG₄ biotin acid offers significantly superior solubility and performance characteristics compared to the traditional, highly hydrophobic biotinylation reagent known as LC-biotin. Moreover, although dPEG₄ biotin acid and LC-biotin have comparable linker lengths, dPEG₄ biotin acid will not trigger the aggregation and precipitation of conjugated biomolecules, even at high levels of biotin incorporation on the biomolecule. In contrast, LC-biotin triggers the aggregation and precipitation of biomolecules with the incorporation of a few LC-biotin groups onto the biomolecule.

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법적 정보

Products Protected under U.S. Patent #s 7,888,536 & 8,637,711 and European Patent #s 1,594,440 & 2,750,681

dPEG is a registered trademark of Quanta BioDesign

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable