C66056
4-(4-Chlorophenyl)-4-hydroxypiperidine
99%
동의어(들):
Haloperidol metabolite I, 4-(4-Chlorophenyl)-4-hydroxypiperidine, 4-(4-Chlorophenyl)-4-piperidinol
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모든 사진(1)
About This Item
실험식(Hill 표기법):
C11H14ClNO
CAS Number:
Molecular Weight:
211.69
EC Number:
MDL number:
UNSPSC 코드:
12352100
PubChem Substance ID:
NACRES:
NA.22
추천 제품
분석
99%
형태
powder
mp
137-140 °C (lit.)
SMILES string
OC1(CCNCC1)c2ccc(Cl)cc2
InChI
1S/C11H14ClNO/c12-10-3-1-9(2-4-10)11(14)5-7-13-8-6-11/h1-4,13-14H,5-8H2
InChI key
LZAYOZUFUAMFLD-UHFFFAOYSA-N
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신호어
Danger
유해 및 위험 성명서
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Dam. 1 - Skin Irrit. 2 - Skin Sens. 1
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
dust mask type N95 (US), Eyeshields, Gloves
A B Skorniakova et al.
Sudebno-meditsinskaia ekspertiza, 52(1), 45-48 (2009-04-18)
Haloperidol is extensively used in current psychiatric practice for the treatment of various psychotic disorders. However, this substance is known to be toxic and sometimes cause poisoning despite its generally positive therapeutic effect. Moreover, some of its metabolites also possess
Yasuhiko Higashi et al.
Biomedical chromatography : BMC, 20(9), 964-970 (2006-03-01)
4-(4-Chlorophenyl)-4-hydroxypiperidine (CPHP), one of the metabolites of haloperidol, is considered to exhibit brain toxicity. CPHP concentrations in plasma and tissue homogenates (each 200 microL) from rats were analyzed by HPLC fluorescence detection after pre-column derivatization with 4-fluoro-7-nitro-2,1,3-benzoxadiazole (NBD-F). After basic
Ilse Weuts et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 25(4-5), 387-393 (2005-05-17)
The purpose of the study was to investigate the suitability of polyacrylic acid (PAA) as a carrier in solid dispersions, with the aim to delay crystallization of basic drugs and improve their dissolution behaviour. The physicochemical properties were investigated in
J Fang et al.
Journal of chromatography. B, Biomedical applications, 682(2), 283-288 (1996-07-12)
An electron-capture gas chromatographic procedure was developed for the analysis of 4-(4-chlorophenyl)-4-hydroxypiperidine (CPHP), a metabolite of haloperidol. The assay involved basic extraction of this metabolite from the biological samples, followed by back-extraction with HCl. After basification of the acid phase
L P Pan et al.
Pharmacogenetics, 8(5), 383-389 (1998-11-24)
In-vitro studies were performed using human liver microsomes and c-DNA-expressed human P450 isoforms to identify the cytochrome P450 isoenzyme(s) involved in the back oxidation and N-dealkylation of reduced haloperidol. Back oxidation and N-dealkylation of reduced haloperidol were assessed by measuring
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