936529

(S,R,S)-AHPC-CO-PEG4-C2-acid

≥95%

• 동의어(들): (S)-18-[(2S,4R)-4-Hydroxy-2-[[4-(4-methylthiazol-5-yl)benzyl]carbamoyl]pyrrolidine-1-carbonyl]-19,19-dimethyl-16-oxo-4,7,10,13-tetraoxa-17-azaicosanoic acid, (S)-18-[[(2S,4R)-4-Hydroxy-2-[[4-(4-methylthiazol-5-yl)benzyl]carbamoyl]pyrrolidin-1-yl]carbonyl]-19,19-dimethyl-16-oxo-4,7,10,13-tetraoxa-17-azaicosanoic acid, L-Prolinamide, N-(15-carboxy-1-oxo-4,7,10,13-tetraoxapentadec-1-yl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-
• 실험식(Hill 표기법): C₃₄H₅₀N₄O₁₀S
• CAS Number: 2172820-12-9
• Molecular Weight: 706.85
• MDL number: MFCD32693336
• UNSPSC 코드: 12352106
• NACRES: NA.22

속성

• ligand: VH032
• Quality Level: 100
• 분석: ≥95%
• 양식: powder or crystals
• 색상: White to Beige
• 저장 온도: 2-8°C
• SMILES string: C([C@@H](NC(CCOCCOCCOCCOCCC(O)=O)=O)[C@](C)(C)C)(=O)N1[C@H](C(NCC2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1
• InChI: 1S/C34H50N4O10S/c1-23-30(49-22-36-23)25-7-5-24(6-8-25)20-35-32(43)27-19-26(39)21-38(27)33(44)31(34(2,3)4)37-28(40)9-11-45-13-15-47-17-18-48-16-14-46-12-10-29(41)42/h5-8,22,26-27,31,39H,9-21H2,1-4H3,(H,35,43)(H,37,40)(H,41,42)/t26-,27+,31-/m1/s1

설명

애플리케이션

(S,R,S)-AHPC-CO-PEG4-C2-acid is a functionalized von Hippel-Lindau (VHL) ligand. It contains a terminal carboxyl group for conjugation with amine linkers. A basic building block for development of a protein degrader library.

Technology Spotlight:

Degrader Building Blocks for Targeted Protein Degradation
Protein Degrader Building Blocks

기타 정보

Targeted Protein Degradation by Small Molecules
Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG
Small-Molecule PROTACS: New Approaches to Protein Degradation
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
Impact of linker length on the activity of PROTACs

법적 정보

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable