934291

Thalidomide-O-amido-C₈-NH₂ trifluoroacetate

≥95.0%

• 동의어(들): N-(8-Aminooctyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide trifluoroacetate
• 실험식(Hill 표기법): C₂₃H₃₀N₄O₆·C₂HF₃O₂
• CAS Number: 1950635-16-1
• Molecular Weight: 572.53
• UNSPSC 코드: 12352200
• NACRES: NA.21

속성

• ligand: thalidomide
• Quality Level: 100
• 분석: ≥95.0%
• 형태: powder or crystals
• 저장 온도: 2-8°C
• SMILES string: O=C(C(F)(F)F)[O-].O=C(COC1=CC=CC(C(N2C3C(NC(CC3)=O)=O)=O)=C1C2=O)NCCCCCCCC[NH3+]

설명

애플리케이션

A functionalized cereblon ligand for development of Thalidomide based PROTACs. Allows rapid conjugation with carboxyl linkers due to presence of amine group via peptide coupling reactions. Amenable for linker attachement via reductive amination, and a basic building block for making protein degrader library.

Technology Spotlight:

Degrader Building Blocks for Targeted Protein Degradation

Protein Degrader Building Blocks

기타 정보

Targeted Protein Degradation by Small Molecules

Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

법적 정보

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

안전성 정보

• 픽토그램: GHS06,GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H301,H312,H360D
• 예방조치 성명서: P202 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P362 + P364
• Hazard Classifications: Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Repr. 1A
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable