934232

Pomalidomide-2,6-diazaspiro[3.3]heptane

≥95.0%

• 동의어(들): 1H-Isoindole-1,3(2H)-dione, 5-(2,6-diazaspiro[3.3]hept-2-yl)-2-(2,6-dioxo-3-piperidinyl), 5-(2,6-Diazaspiro[3.3]heptan-2-yl)-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione
• 실험식(Hill 표기법): C₁₈H₁₈N₄O₄
• CAS Number: 2226301-50-2
• Molecular Weight: 354.36
• UNSPSC 코드: 12352200
• NACRES: NA.21

속성

• ligand: pomalidomide
• Quality Level: 100
• 분석: ≥95.0%
• 양식: powder or crystals
• 색상: off-white to light yellow
• 저장 온도: 2-8°C
• SMILES string: O=C1N(C2CCC(NC2=O)=O)C(C3=CC=C(N4CC5(CNC5)C4)C=C31)=O
• InChI: 1S/C18H18N4O4/c23-14-4-3-13(15(24)20-14)22-16(25)11-2-1-10(5-12(11)17(22)26)21-8-18(9-21)6-19-7-18/h1-2,5,13,19H,3-4,6-9H2,(H,20,23,24)
• InChI key: ZJRIIJGHSAJWMI-UHFFFAOYSA-N

설명

애플리케이션

Pomalidomide-2,6-diazaspiro[3.3]heptane Hydrochloride is a functionalized Cereblon ligand used for development of protein degrader building blocks. Contains a terminal amine group, allowing rapid conjugation of carboxyl containing linkers. A basic building block for development of a protein degrader library.

Technology Spotlight:
Degrader Building Blocks for Targeted Protein Degradation

Protein Degrader Building Blocks

기타 정보

Targeted Protein Degradation by Small Molecules

Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

법적 정보

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

안전성 정보

• 픽토그램: GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H360D
• 예방조치 성명서: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 1B
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable