909661

d0-DMDSSO crosslinker

≥95%

• 동의어(들): Bis(2,5-dioxopyrrolidin-1-yl) 3,3′-sulfinylbis(2-methylpropanoate), Mass spectrometry-cleavable crosslinker for studying protein-protein interactions
• 실험식(Hill 표기법): C₁₆H₂₀N₂O₉S
• CAS Number: 1554583-88-8
• Molecular Weight: 416.40
• UNSPSC 코드: 12352106

속성

• 분석: ≥95%
• 형태: powder
• 저장 온도: 2-8°C

설명

애플리케이션

d0-DMDSSO (dimethyl-disuccinimidyl sulfoxide) crosslinker is a homobifunctional, lysine residue-targeting, sulfoxide-containing crosslinker for analysis of protein-protein interactions (PPIs) through crosslinking mass spectrometry (XL-MS). d0-DMDSSO possesses two N-hydroxysuccinimide (NHS) ester groups for targeting amines and two symmetrical C-S cleavable bonds adjacent to the central sulfoxide. The post-cleavage spacer yields tagged peptides for unambiguous identification by collision-induced dissociation in tandem MS. d0-DMDSSO crosslinker will also be a useful proteomics tool and aid in the quest for targeting ″undruggable″ protein targets.

기타 정보

Technology Spotlight: Cross-Linkers for Elucidation of Protein-Protein Interactions

Developing New Isotope-Coded Mass Spectrometry-Cleavable Cross-Linkers for Elucidating Protein Structures

법적 정보

Subject to US Patent Application #15/275,001 of the Regents of the University of California

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable