906301
BTTES
동의어(들):
3-(4-((Bis((1-(tert-butyl)-1H-1,2,3-triazol-4-yl)methyl)amino)methyl)-1H-1,2,3-triazol-1-yl)propane-1-sulfonic acid, Copper click-chemistry ligand, Water-soluble CuAAC ligand
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모든 사진(1)
About This Item
실험식(Hill 표기법):
C20H34N10O3S
CAS Number:
Molecular Weight:
494.61
MDL number:
UNSPSC 코드:
12161600
추천 제품
![Tris[(1-benzyl-1H-1,2,3-triazol-4-yl)methyl]amine 97%](/deepweb/assets/sigmaaldrich/product/structures/179/695/86a721c8-2a4c-4e4f-bc36-6276ce7a941f/640/86a721c8-2a4c-4e4f-bc36-6276ce7a941f.png)
![Tetrakis[tris(dimethylamino)phosphoranylidenamino]phosphonium chloride 95%](/deepweb/assets/sigmaaldrich/product/structures/160/963/9dd6d457-17b2-44dc-8ea2-d3c0475b3664/640/9dd6d457-17b2-44dc-8ea2-d3c0475b3664.png)
양식
solid
반응 적합성
reaction type: click chemistry
재고 정보
available only in USA
저장 온도
2-8°C
SMILES string
[S](=O)(=O)(O)CCC[n]1nnc(c1)CN(Cc3nn[n](c3)C(C)(C)C)Cc2nn[n](c2)C(C)(C)C
InChI
1S/C20H34N10O3S/c1-19(2,3)29-14-17(22-25-29)11-27(12-18-15-30(26-23-18)20(4,5)6)10-16-13-28(24-21-16)8-7-9-34(31,32)33/h13-15H,7-12H2,1-6H3,(H,31,32,33)
InChI key
WMEZDVILBKIODK-UHFFFAOYSA-N
애플리케이션
BTTES is a a next-generation, water-soluble ligand for the copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) that accelerates reaction rates and suppresses cell cytotoxicity. The biocompatibility and fast kinetics of BTTES are advancements from water-insoluble TBTA and are desirable for bioconjugation in diverse chemical biology experiments.
신호어
Danger
유해 및 위험 성명서
Hazard Classifications
Self-react. C
Storage Class Code
5.2 - Organic peroxides and self-reacting hazardous materials
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Wei Wang et al.
Chemistry, an Asian journal, 6(10), 2796-2802 (2011-09-10)
The copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC), the prototypical reaction of click chemistry, is accelerated by tris(triazolylmethyl)amine-based ligands. Herein, we compare two new ligands in this family--3-[4-({bis[(1-tert-butyl-1H-1,2,3-triazol-4-yl)methyl]amino}methyl)-1H-1,2,3-triazol-1-yl]propanol (BTTP) and the corresponding sulfated ligand 3-[4-({bis[(1-tert-butyl-1H-1,2,3-triazol-4-yl)methyl]amino}methyl)-1H-1,2,3-triazol-1-yl]propyl hydrogen sulfate (BTTPS)--for three bioconjugation applications: 1) labeling
David Soriano Del Amo et al.
Journal of the American Chemical Society, 132(47), 16893-16899 (2010-11-11)
The Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) is the standard method for bioorthogonal conjugation. However, current Cu(I) catalyst formulations are toxic, hindering their use in living systems. Here we report that BTTES, a tris(triazolylmethyl)amine-based ligand for Cu(I), promotes the cycloaddition reaction rapidly
Christen Besanceney-Webler et al.
Angewandte Chemie (International ed. in English), 50(35), 8051-8056 (2011-07-16)
Raising the bar: the efficacy of bioorthogonal reactions for bioconjugation has been thoroughly evaluated in four different biological settings. Powered by the development of new biocompatible ligands, the copper-catalyzed azide-alkyne cycloaddition has brought about unsurpassed bioconjugation efficiency, and thus it
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