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Merck
모든 사진(1)

Key Documents

904643

Sigma-Aldrich

Thiol functionalized gelatin

동의어(들):

Functionalized gelatin, Gelatin thiol, Gelatin-SH• Gel-SH, SH functionalized gelatin, Thiol functionalized gelatin, Thiol gelatin, Thiolated gelatin

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About This Item

UNSPSC 코드:
12352105
NACRES:
NA.23

설명

NMR: Conforms to structure
Thiol content 150-350 μmol/g

분석

150-350 μmol/g (Free Thiol Concentration by UVVI, UV-vis)

형태

powder

색상

white to pale yellow

저장 온도

−20°C

애플리케이션

Gelatin has received significant attention in the biomedical field due to its inherent bioactivity. Functionalized gelatin can be cross-linked with the formation of covalent bonds into highly crosslinked structures, such as hydrogels. Recent literature suggests that radical-mediated polymerized hydrogels may not be ideal for cell and protein encapsulation due to radical-mediated damage, hindered molecular transport, or altered cell-cell/cell-material interactions. Thiol-modified gelatin can be used to form hydrogels with multifunctional norbornene or allyl crosslinkers via thiol-ene click or Michael-addition reactions.
To improve solubility in water, heat to 40°C and stir for 10-15 minutes.

주의사항

Material should be handled under nitrogen - air/oxygen & moisture are to be avoided.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


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문서 라이브러리 방문

Gelatin hydrogels formed by orthogonal thiol?norbornene photochemistry for cell encapsulation
Munoz Z, et al.
Biomaterials Science, 2, 1063-1072 (2014)
Vinh X Truong et al.
Biomacromolecules, 18(3), 757-766 (2017-02-15)
Swelling of hydrogels leads to a decrease in mechanical performance coupled with complications in solute diffusion. In addition, hydrogel swelling affects patient safety in biomedical applications such as compression of tissue and fluid blockage. A conventional strategy for suppressing swelling
Modular Cross-Linking of Gelatin-Based Thiol?Norbornene Hydrogels for in Vitro 3D Culture of Hepatocellular Carcinoma Cells
Greene T, et al
ACS biomaterials science & engineering, 1 (12), 1314?1323-1314?1323 (2015)

문서

Professor Shrike Zhang (Harvard Medical School, USA) discusses advances in 3D-bioprinted tissue models for in vitro drug testing, reviews bioink selections, and provides application examples of 3D bioprinting in tissue model biofabrication.

Professor Shrike Zhang (Harvard Medical School, USA) discusses advances in 3D-bioprinted tissue models for in vitro drug testing, reviews bioink selections, and provides application examples of 3D bioprinting in tissue model biofabrication.

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