추천 제품
양식
crystals
분자량
Mn 60,000-110,000 Da by MALLS (GPC)
average Mn 85,000
색상
white to off-white
mp
96 °C
저장 온도
2-8°C
SMILES string
CC(C)NC(=O)C=C
InChI
1S/C6H11NO/c1-3-5-7-6(8)4-2/h4H,2-3,5H2,1H3,(H,7,8)
InChI key
WDFKEEALECCKTJ-UHFFFAOYSA-N
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일반 설명
Poly(N-isopropylacrylamide) (PNIPAM) is a temperature-responsive polymer used in biomedical research applications. PNIPAM undergoes a reversible, lower critical solution temperature (LCST) phase transition when heated above 32 °C, transitioning from a soluble to an insoluble material. PNIPAM is also frequently crosslinked to yield hydrogels with reversible, thermal shrinking and swelling. Poly(N-isopropylacrylamide) is also readily functionalized and has been used as the hydrophilic block in the synthesis of thermoresponsive, amphiphilic block copolymers. Due to the similarity in temperature between the LCST of PNIPAM and the temperature of the human body, PNIPAM materials have been frequently utilized in tissue engineering and controlled drug delivery research applications.
애플리케이션
PNIPAM can be used in the formation of a smart hydrogel, which finds potential usage in sensors, fuel cells, supercapacitors, and lithium-ion batteries. It can also be used in the fabrication of molecular nanothermometer. PNIPAM is coated with gold nanoparticles (AuNPs) to form microgels that facilitate highly reproducible signals for surface-enhanced Raman scattering (SERS).
Thermosensitive polymer, can be used to form a hydrogel. Aqueous polymer solution undergoes a phase transition from a soluble to an insoluble state when the temperature is raised to ca. 32 °C.
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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이미 열람한 고객
Au@ pNIPAM colloids as molecular traps for surface-enhanced, spectroscopic, ultra-sensitive analysis
Alvarez-Puebla RA, et al.
Angewandte Chemie (International ed. in English), 48(1), 138-143 (2009)
S Panja et al.
ACS applied materials & interfaces, 8(19), 12063-12074 (2016-04-30)
The design of nanomedicines from the tuned architecture polymer is a leading object of immense research in recent years. Here, smart thermoresponsive micelles were prepared from novel architecture four-arm star block copolymers, namely, pentaerythritol polycaprolactone-b-poly(N-isopropylacrylamide) and pentaerythritol polycaprolactone-b-poly(N-vinylcaprolactam). The polymers
Synthesis of hyperbranched polyglycidol-b-poly(N-isopropylacrylamide) using nitroxide-mediated polymerization for thermo-sensitive drug delivery system.
Min Seon Heo et al.
Journal of controlled release : official journal of the Controlled Release Society, 213, e80-e80 (2016-03-24)
Muhammad Abdul Haq et al.
Materials science & engineering. C, Materials for biological applications, 70(Pt 1), 842-855 (2016-10-25)
Materials which adjust their properties in response to environmental factors such as temperature, pH and ionic strength are rapidly evolving and known as smart materials. Hydrogels formed by smart polymers have various applications. Among the smart polymers, thermoresponsive polymer poly(N-isopropylacrylamide)(PNIPAM)
Nanorod-coated PNIPAM microgels: thermoresponsive optical properties
Karg M, et al.
Small, 3(7), 1222-1229 (2007)
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