712264

Cytisine

≥99.0% (HPLC), ≥99%

• 동의어(들): (−)-Cytisine, (1R,5S)-1,2,3,4,5,6-Hexahydro-1,5-methano-8H-pyrido[1,2a][1,5]diazocin-8-one, (1S,9S)-3,11-Diazatricyclo[7.3.1.0^3,8]trideca-5,7-dien-4-one, Baptitoxin, Laburnin, Sophorine, Ulexine
• 실험식(Hill 표기법): C₁₁H₁₄N₂O
• CAS Number: 485-35-8
• Molecular Weight: 190.24
• EC Number: 207-616-0
• MDL number: MFCD00136048
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329763123
• NACRES: NA.22

속성

• Quality Level: 100
• 분석: ≥99%; ≥99.0% (HPLC)
• 형태: powder
• 광학 활성: [α]/D -108±3°, c = 1% in ethanol
• bp: 218 °C/2 mmHg (lit.)
• mp: 154-156 °C (lit.)
• SMILES string: O=C1C=CC=C2C3CNCC(C3)CN12
• InChI: 1S/C11H14N2O/c14-11-3-1-2-10-9-4-8(5-12-6-9)7-13(10)11/h1-3,8-9,12H,4-7H2/t8-,9+/m0/s1
• InChI key: ANJTVLIZGCUXLD-DTWKUNHWSA-N

설명

일반 설명

Cystine ((1R,5S)-1,2,3,4,5,6-hexahydro-1,5-methano-8H-pyrido[1,2a][1,5]diazocin-8-one) displays classical antidepressant action in various animal models of antidepressant efficacy. Infrared and Raman spectral studies suggest that it has two stable conformers.

Cytisine was found to be more effective than nicotine-replacement therapy in helping smokers to quit smoking. It is an α₄ β₂ nicotinic receptor partial agonist. It is a plant alkaloid which is commercially extracted for use as a smoking cessation medication. Preparation of nicotine partial agonist cytisine via “in situ” Stille or Suzuki biaryl pyridine coupling has been reported. Cytisine is a competitive partial agonist at α4 subunit-containing nicotinic acetylcholine (nACh) receptors while at homomeric α7-nACh receptors it behaves as a full agonist with a relatively lower potency.

애플리케이션

Cystine may be used as nicotine substitute in nicotine addiction therapy.

Cytisine is suitable for use in a study to compare the effects of varenicline and cytisine on ethanol consumption by rats bred for many generations as high ethanol drinkers.

생화학적/생리학적 작용

Potent agonist at α3β4 and α7 nicotinic acetylcholine receptors and partial agonist at α4β2 nicotinic acetylcholine receptors.

포장

Bottomless glass bottle. Contents are inside inserted fused cone.

안전성 정보

• 픽토그램: GHS06
• 신호어: Danger
• 유해 및 위험 성명서: H301 + H311 + H331
• 예방조치 성명서: P261 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges