691399

Chlorosulfonyl isocyanate

Arxada quality, 99.0-100.3 % (w/w) (T)

• 동의어(들): N-Carbonylsulfamyl chloride, CSI
• Linear Formula: ClSO₂NCO
• CAS Number: 1189-71-5
• Molecular Weight: 141.53
• Beilstein: 1237247
• EC Number: 214-715-2
• MDL number: MFCD00011608
• UNSPSC 코드: 12352100
• PubChem Substance ID: 329761405
• NACRES: NA.22

속성

• vapor pressure: 5.57 psi ( 20 °C)
• Quality Level: 100
• 형태: liquid
• 품질: Arxada quality
• 제조업체/상표: Arxada AG
• 농도: 99.0-100.3 % (w/w) (T)
• 불순물: ≤1.00% chloropropylsulfonyl isocyanate
• refractive index: n20/D 1.447 (lit.)
• bp: 107 °C (lit.)
• mp: −44 °C (lit.)
• density: 1.626 g/mL at 25 °C (lit.)
• SMILES string: ClS(=O)(=O)N=C=O
• InChI: 1S/CClNO3S/c2-7(5,6)3-1-4
• InChI key: WRJWRGBVPUUDLA-UHFFFAOYSA-N

설명

애플리케이션

• Pharmaceutical intermediates: A study explored the synthesis and carbonic anhydrase inhibitory properties of sulfamides derived from Chlorosulfonyl isocyanate, demonstrating its potential in the development of new therapeutic agents, particularly for treating conditions involving carbonic anhydrase enzymes (Aksu et al., 2013).
• Stereochemical synthesis applications: Chlorosulfonyl isocyanate was utilized for the stereoselective amination of chiral benzylic ethers in the total synthesis of (+)-sertraline, showcasing its critical role in the precise construction of complex pharmaceuticals (Lee et al., 2011).
• One-pot synthetic transformations: The compound′s use in one-pot conversion of trimethylsilyl ethers into urethanes was highlighted, further applied to synthesize novel neuromodulators like carisbamate. This illustrates Chlorosulfonyl isocyanate′s versatility in facilitating efficient and innovative synthetic routes in medicinal chemistry (Dong et al., 2008).

안전성 정보

• 픽토그램: GHS08,GHS05,GHS07
• 신호어: Danger
• 유해 및 위험 성명서: H302,H314,H317,H334
• 예방조치 성명서: P261 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Dam. 1 - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1
• 보충제 위험성: EUH014
• Storage Class Code: 8A - Combustible corrosive hazardous materials
• WGK: WGK 3
• Flash Point (°F): >230.0 °F
• Flash Point (°C): > 110 °C
• 개인 보호 장비: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter