460923
Propargyl chloroformate
96%
동의어(들):
(Prop-2-ynyloxy)carbonyl chloride, 2-Propyn-1-yl carbonochloridate, 2-Propynyl chloroformate, Prop-2-yn-1-yl carbonochloridate, Propargyloxycarbonyl chloride
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모든 사진(1)
About This Item
Linear Formula:
HC≡CCH2OCOCl
CAS Number:
Molecular Weight:
118.52
Beilstein:
1745399
MDL number:
UNSPSC 코드:
12352100
PubChem Substance ID:
NACRES:
NA.22
추천 제품
vapor pressure
0.65 psi ( 20 °C)
분석
96%
반응 적합성
reaction type: click chemistry
refractive index
n20/D 1.435 (lit.)
bp
118-122 °C (lit.)
density
1.215 g/mL at 25 °C (lit.)
작용기
chloro
저장 온도
2-8°C
SMILES string
ClC(=O)OCC#C
InChI
1S/C4H3ClO2/c1-2-3-7-4(5)6/h1H,3H2
InChI key
RAMTXCRMKBFPRG-UHFFFAOYSA-N
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일반 설명
Propargyl chloroformate is a propargyl ester. It serves as a protecting group for the hydroxy and amino functional group. Rates of solvolysis of propargyl chloroformate has been analyzed in various solvents of widely varying nucleophilicity and ionizing power values using the extended Grunwald-Winstein equation.
애플리케이션
Propargyl chloroformate may be used for the preparation of the following:
- binaphthol-diacetylene derivatives
- propargyl pentafluorophenyl carbonate
- N-Poc protected amino acids (Poc = propargyloxycarbonyl)
신호어
Danger
유해 및 위험 성명서
Hazard Classifications
Acute Tox. 4 Oral - Flam. Liq. 3 - Skin Corr. 1B
Storage Class Code
3 - Flammable liquids
WGK
WGK 3
Flash Point (°F)
86.0 °F - closed cup
Flash Point (°C)
30 °C - closed cup
개인 보호 장비
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
이미 열람한 고객
Organogold (I) complexes of a C 2-symmetric diacetylide ligand derived from 1, 1'-bi-2-naphthol.
Burchell TJ, et al.
Inorgorganica Chimica Acta, 359(9), 2812-2818 (2006)
Propargyloxycarbonyl and propargyl groups for novel protection of amino, hydroxy, and carboxy functions.
Fukase Y, et al.
Tetrahedron Letters, 40(6), 1169-1170 (1999)
Malcolm J D'Souza et al.
ISRN organic chemistry, 2011 (2011-06-15)
The specific rates of solvolysis of propargyl chloroformate (1) are analyzed in 22 solvents of widely varying nucleophilicity and ionizing power values at 25.0 °C using the extended Grunwald-Winstein equation. Sensitivities to solvent nucleophilicity (l) of 1.37 and to solvent
Propargyloxycarbonyl (Poc) amino acid chlorides as efficient coupling reagents for the synthesis of 100% diastereopure peptides and resin bound tetrathiomolybdate as an effective deblocking agent for the Poc group.
Bhat RG, et al.
Chemical Communications (Cambridge, England), 8, 812-813 (2002)
Synthesis and applications of propargyl pentafluorophenyl carbonate for peptide synthesis.
Bhat RG, et al.
Tetrahedron Letters, 43(13), 2467-2469 (2002)
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