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일반 설명
Hydroxylamine is a weak base that is mainly used as a reducing agent in organic reactions.
애플리케이션
Reactant for preparation of:
- Prodrug for cardiovascular agent Nω-hydroxy-L-arginine (NOHA, nitric oxide precursor)
- Hydroxyaminoguanidines as anti-cancer agents
- Nonsteroidal 2,3-dihydroquinoline glucocorticoid receptor agonists with reduced phosphoenolpyruvate caboxykinase (PEPCK) transactivation
- Carboxamide derivatives of ofloxacin with improved antimicrobial properties
- Analogues of coumarin based TNF-α converting enzyme (TACE) inhibitors
- HIV integrase inhibitors
신호어
Danger
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1 - Carc. 2 - Desen. Expl. 4 - Eye Dam. 1 - Met. Corr. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 2 - STOT SE 3
표적 기관
Blood, Respiratory system
Storage Class Code
3 - Flammable liquids
WGK
WGK 3
개인 보호 장비
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Elie Akanny et al.
Analytical and bioanalytical chemistry, 411(21), 5563-5576 (2019-06-19)
The Surface-enhanced Raman spectroscopy (SERS) method based on gold nanoparticles as SERS substrate was investigated for the label-free detection and quantification of probiotic bacteria that are widely used in various pharmaceutical formulations. Indeed, the development of a simple and fast
Reducing graphene oxide via hydroxylamine: a simple and efficient route to graphene.
Zhou X, et al.
The Journal of Physical Chemistry C, 115(24), 11957-11961 (2011)
Assembly of cyclic peptide dendrimers from unprotected linear building blocks in aqueous solution.
DavidaPallin T.
Chemical Communications (Cambridge, England), 11, 1345-1346 (1996)
A E Cribb et al.
Clinical pharmacology and therapeutics, 51(5), 522-526 (1992-05-01)
The oxidation of sulfamethoxazole to its hydroxylamine metabolite was investigated in vitro with human liver microsomes and in vivo by detection in the urine. Sulfamethoxazole was oxidized to the hydroxylamine in an NADPH-dependent process by liver microsomes prepared from two
Claire-Lise Ciana et al.
Bioorganic & medicinal chemistry letters, 23(3), 658-662 (2012-12-25)
A novel series of anti-malarials, based on a hydroxy-ethyl-amine scaffold, initially identified as peptidomimetic protease inhibitors is described. Combination of the hydroxy-ethyl-amine anti-malarial phramacophore with the known Mannich base pharmacophore of amodiaquine (57) resulted in promising in vivo active novel
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