10907
Chloroacetaldehyde solution
Wacker Chemie AG, produced by Wacker Chemie AG, Burghausen, Germany, ≥45.0% in H2O (density determination)
동의어(들):
CLACH
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모든 사진(1)
About This Item
Linear Formula:
ClCH2CHO
CAS Number:
Molecular Weight:
78.50
Beilstein:
1071226
EC Number:
MDL number:
UNSPSC 코드:
12352100
PubChem Substance ID:
NACRES:
NA.22
추천 제품
Grade
produced by Wacker Chemie AG, Burghausen, Germany
양식
solid
제조업체/상표
Wacker Chemie AG
농도
≥45.0% in H2O (density determination)
bp
80-100 °C (lit.)
작용기
aldehyde
chloro
SMILES string
[H]C(=O)CCl
InChI
1S/C2H3ClO/c3-1-2-4/h2H,1H2
InChI key
QSKPIOLLBIHNAC-UHFFFAOYSA-N
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애플리케이션
Chloroacetaldehyde is a reagent used for converting adenine and its nucleoseides into fluorescent etheno derivatives which can be analysed by HPLC. It was used for derivatization in fluorometric determination of arprinocid and analogous compounds in human plasma .
생화학적/생리학적 작용
Chloroacetaldehyde, a metabolite of ifosamide, influences oxidative phosphorylation in mitochondria. It causes breaking of DNA strands and strongly inhibits DNA synthesis.
기타 정보
prices for bulk quantities on request
신호어
Danger
유해 및 위험 성명서
Hazard Classifications
Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 3 Oral - Aquatic Acute 1 - Carc. 2 - Eye Dam. 1 - Skin Corr. 1B - STOT SE 3
표적 기관
Respiratory system
Storage Class Code
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
Flash Point (°F)
143.6 °F - closed cup
Flash Point (°C)
62 °C - closed cup
개인 보호 장비
Eyeshields, Gloves, type ABEK (EN14387) respirator filter
Preparation, titration, and storage of chloroacetaldehyde for fluorometric determination of adenine and its derivatives.
McCann WP, et al.
Analytical Chemistry, 55(8), 1454-1455 (1983)
Svenja K Brüggemann et al.
Cancer chemotherapy and pharmacology, 57(3), 349-356 (2005-09-01)
The ifosfamide metabolite chloroacetaldehyde had been made responsible for side effects only. We found in previous studies a strong cytotoxicity on human MX-1 tumor cells and xenografts in nude mice. Chloroacetaldehyde is supposed to act via alkylation or by inhibition
Fluorogenic reaction between adenine derivatives and chloroacetaldehyde and its application to the determination of 9-(2-chloro-6-fluorobenzyl) adenine in human plasma.
Matuszewski BK and Bayne WF.
Analytica Chimica Acta, 227, 189-202 (1989)
V Nagarajavel et al.
The Journal of biological chemistry, 282(32), 23622-23630 (2007-06-16)
H-NS inhibits transcription by forming repressing nucleoprotein complexes next to promoters. We investigated repression by binding of H-NS within the transcription unit using the bgl and proU operons. Repression of both operons requires a downstream regulatory element (DRE) in addition
Zeinab Yaseen et al.
Archives of toxicology, 82(9), 607-614 (2008-01-25)
The Fanconi syndrome is a common side effect of the chemotherapeutic agent ifosfamide. Current evidences suggest that chloroacetaldehyde (CAA), one of the main metabolites of ifosfamide activation, contributes to its nephrotoxicity. However, the pathophysiology of CAA-induced Fanconi syndrome is not
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