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Merck

ALOX5

arachidonate 5-lipoxygenase

동의어:
5-LO, 5-LOX, 5LPG, LOG5
:
UniProtKB ID:
Clone ID:
  • Human(240) Summary: This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
  • Mouse(11689) arachidonate 5-lipoxygenase
  • Rat(25290) arachidonate 5-lipoxygenase
  • Zebrafish(573013) arachidonate 5-lipoxygenase
  • chicken(423769) arachidonate 5-lipoxygenase
  • dog(477753) arachidonate 5-lipoxygenase
  • domestic cat(101097422) arachidonate 5-lipoxygenase
  • cow(404074) arachidonate 5-lipoxygenase
  • Horse(100062042) arachidonate 5-lipoxygenase
  • Zebrafish(567204) arachidonate 5-lipoxygenase
  • domestic guinea pig(100718093) arachidonate 5-lipoxygenase
  • naked mole-rat(101700210) arachidonate 5-lipoxygenase
  • sheep(101117390) arachidonate 5-lipoxygenase

Custom & Knockdown Gene Products

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Antibodies

제품 번호
설명
종별 반응성
응용분야
Anti-Arachidonate 5 Lipoxygenase antibody produced in rabbit, affinity isolated antibody,
종별 반응성
human, mouse, rat
응용분야
ELISA
immunohistochemistry

western blot
Anti-5′-Lipoxygenase Antibody, Chemicon®, from rabbit,
종별 반응성
human, mouse, rabbit, rat
응용분야
ELISA
immunoprecipitation (IP)

western blot
Anti-ALOX5 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
종별 반응성
human
응용분야
immunofluorescence
immunohistochemistry
Anti-ALOX5 antibody produced in rabbit, ,
종별 반응성
human, mouse, rat
응용분야
immunohistochemistry
western blot
Anti-Phospho-ALOX5-S271 antibody produced in rabbit, ,
종별 반응성
human
응용분야
western blot

Small Molecule - Inhibitor

제품 번호
설명
Zileuton, ≥98% (HPLC),
human
Zileuton, United States Pharmacopeia (USP) Reference Standard,
human
Isoliquiritigenin, powder,
rat
BW A4C, ≥98% (HPLC),
human, rat
Caffeic acid, ≥98.0% (HPLC),
human, rat

esiRNA

제품 번호
설명
MISSION® esiRNA, targeting human ALOX5,
human
MISSION® esiRNA, targeting mouse Alox5,
mouse