추천 제품
Quality Level
분석
≥98% (HPLC)
형태
powder
저장 조건
protect from light
색상
white
mp
79.3-80.1 °C (lit.)
solubility
DMSO: 20 mg/mL
저장 온도
2-8°C
SMILES string
CC(=O)N(O)C\C=C\c1cccc(Oc2ccccc2)c1
InChI
1S/C17H17NO3/c1-14(19)18(20)12-6-8-15-7-5-11-17(13-15)21-16-9-3-2-4-10-16/h2-11,13,20H,12H2,1H3/b8-6+
InChI key
CEUDWZXMLMKPNN-SOFGYWHQSA-N
유전자 정보
human ... ALOX5(240)
rat ... Alox5(25290)
생화학적/생리학적 작용
Selective 5-lipoxygenase (5-LOX) inhibitor. Inhibits synthesis of LTB4.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
K Nakahama et al.
Prostaglandins, leukotrienes, and essential fatty acids, 51(3), 177-182 (1994-09-01)
The role of endogenously produced arachidonic acid metabolites on glomerulonephritis was investigated using cultured rat mesangial cells. The cultured mesangial cells could produce prostaglandin (PG) E2 and F2 alpha and 12-hydroxyeicosatetraenoic acid (12-HETE). The treatment of the mesangial cells with
C Franchi-Miller et al.
Bone, 17(2), 185-191 (1995-08-01)
The role of leukotrienes on bone resorption was tested in a well-standardized model of bone remodeling by inhibiting their biosynthesis with BWA4C, a specific inhibitor of 5-lipoxygenase. After extraction of their upper molars unilaterally, 30 Wistar rats were divided into
S Gök et al.
General pharmacology, 29(5), 789-792 (1997-11-05)
1. The effects of a lipoxygenase inhibitor, BW A4C, on digoxin-induced arrhythmias and cardiac dynamics (contractile force, perfusion pressure, heart rate) were investigated in Langendorff-perfused isolated guinea-pig hearts. In the control group, arrhythmias were induced by 25 micrograms/ml digoxin at
S A Yasin et al.
Journal of neuroendocrinology, 6(2), 179-184 (1994-04-01)
Interleukin-1 (IL-1) and interleukin-6 (IL-6) have been reported to stimulate the release of corticotrophin-releasing hormone (CRH) in vitro, the response being antagonized by the cyclo-oxygenase inhibitor, indomethacin. The effects of cytokines on the other major ACTH-releasing hormone, vasopressin (AVP), and
I D Brodowsky et al.
European journal of pharmacology, 254(1-2), 43-47 (1994-03-11)
Linoleic acid is converted to 8R-hydroperoxylinoleic acid by the soluble 8R-dioxygenase of the fungus Gaeumannomyces graminis. Effects of different lipoxygenase inhibitors on the 8R-dioxygenase were evaluated. Three hydroxamic acid derivatives were investigated. BW A4C (N-(3-phenoxycinnamyl)acetohydroxamic acid) was the most potent
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