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Key Documents

P4670

Sigma-Aldrich

Propafenone hydrochloride

Synonym(s):

1-[2-(2-Hydroxy-3-(propylamino)propoxy)phenyl]-3-phenyl-1-propanone hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C21H27NO3 · HCl
CAS Number:
Molecular Weight:
377.90
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.77

form

powder

Quality Level

originator

Abbott

storage temp.

2-8°C

SMILES string

Cl[H].CCCNCC(O)COc1ccccc1C(=O)CCc2ccccc2

InChI

1S/C21H27NO3.ClH/c1-2-14-22-15-18(23)16-25-21-11-7-6-10-19(21)20(24)13-12-17-8-4-3-5-9-17;/h3-11,18,22-23H,2,12-16H2,1H3;1H

InChI key

XWIHRGFIPXWGEF-UHFFFAOYSA-N

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General description

Propafenone hydrochloride is a calcium antagonist. It functions as a Na+ and K+ channel blocker. It might be used to treat patients with systemic hypertension. Propafenone hydrochloride is associated with bradycardia and bronchospasms. It is metabolized in the liver. Propafenone hydrochloride is used to treat ventricular arrhythmias.

Application

Propafenone hydrochloride has been used in the isolation of cardiomyocytes.

Biochem/physiol Actions

Blocks hKv1.5 and ATP-sensitive K+ channels; class 1C antiarrhythmic agent that is also an antagonist at β adrenergic receptors.

Features and Benefits

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3


Certificates of Analysis (COA)

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Propafenone blocks ATP-sensitive K+ channels in rabbit atrial and ventricular cardiomyocytes
Christe G, et al.
European Journal of Pharmacology, 373(2-3), 223-232 (1999)
A Seki et al.
British journal of pharmacology, 126(5), 1153-1162 (1999-04-16)
1. The class Ic anti-arrhythmic agent, flecainide is known to inhibit the transient outward K current (Ito) selectively in human atrium. We studied the effects of propafenone, another class Ic antiarrhythmic agent, on K currents in human atrial myocytes using
Rate control vs rhythm control in patients with nonvalvular persistent atrial fibrillation: the results of the Polish How to Treat Chronic Atrial Fibrillation (HOT CAFE) Study
Opolski G, et al.
Chest, 126(2), 476-486 (2004)
The multiple modes of action of propafenone
Dukes ID and Williams EMV
European Heart Journal, 5(2), 115-125 (1984)
Pharmacologic management of arrhythmias
Ganjehei L, et al.
Texas Heart Institute Journal, 38(4), 344-344 (2011)

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