8.08259

2,2,2-Trifluoroethanol

for synthesis

• Synonym(s): 2,2,2-Trifluoroethanol
• Empirical Formula (Hill Notation): C₂H₃F₃O
• CAS Number: 75-89-8
• Molecular Weight: 100.04
• MDL number: MFCD00004672
• UNSPSC Code: 12352104
• EC Index Number: 200-913-6
• NACRES: NA.22

Properties

• vapor pressure: 70.9 hPa ( 20 °C)
• Quality Level: 200
• Assay: ≥99% (GC)
• form: liquid
• potency: 240 mg/kg LD₅₀, oral (Rat); 1680 mg/kg LD₅₀, skin (Rat)
• expl. lim.: 8.4-28.8 % (v/v)
• pH: 7
• bp: 73.6 °C/1013 hPa
• mp: -43.5 °C
• transition temp: flash point 30 °C
• density: 1.38 g/cm³ at 25 °C
• storage temp.: 2-30°C
• InChI: 1S/C2H3F3O/c3-2(4,5)1-6/h6H,1H2
• InChI key: RHQDFWAXVIIEBN-UHFFFAOYSA-N

Description

General description

2,2,2-Trifluoroethanol (TFE) is a fluorinated compound used as a solvent in organic synthesis. Peptides and proteins are experimentally studied using TEE as a cosolvent. In TFE, hydrogen peroxide is effective for oxidizing sulfur compounds.

Application

2,2,2-Trifluoroethanol is used as a solvent:

• In the preparation of nylon/Ag composite nanofibers by electrospinning method.
• To study the combination of two polymers PANI (polyaniline) and PHB (polyhydroxy-butyrate).

Features and Benefits

2,2,2-Trifluoroethanol is more acidic than ethanol due to the presence of electronegative trifluoromethyl group.

Safety Information

• Pictograms: GHS02,GHS05,GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H226 - H301 + H331 - H318 - H360F - H373
• Precautionary Statements: P202 - P210 - P280 - P301 + P310 - P304 + P340 + P311 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Dam. 1 - Flam. Liq. 3 - Repr. 1B - STOT RE 2 Inhalation
• Target Organs: Blood
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 1
• Flash Point(F): 86.0 °F - closed cup
• Flash Point(C): 30 °C - closed cup