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440744

Sigma-Aldrich

Polycaprolactone

average Mn 80,000

Synonym(s):

2-Oxepanone homopolymer, 6-Caprolactone polymer

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About This Item

Linear Formula:
(C6H10O2)n
UNSPSC Code:
12162002
NACRES:
NA.23

form

pellets (~3 mm)

mol wt

average Mn 80,000

impurities

<0.5% water

mp

60 °C (lit.)

density

1.145 g/mL at 25 °C

Mw/Mn

<2

application(s)

3D bioprinting
advanced drug delivery

SMILES string

C1CCC(=O)OCC1 (Canonical-SMILES)

InChI

1S/C6H10O2/c7-6-4-2-1-3-5-8-6/h1-5H2

InChI key

PAPBSGBWRJIAAV-UHFFFAOYSA-N

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General description

Polycaprolactone (PCL) is a semi crystalline hydrophobic biodegradable polyester which finds major applications as a drug delivery agent because of its cost efficiency, high toughness and biocompatibility. PCL possesses some unique properties such as:
  • It degrades slower than other biodegradable polyesters in physiological condition, this property can be exploited in the controlled release of drugs in target tissues over a period of time.
  • Its poor surface wetting and interaction with biological fluids on account of its hydrophobicity leads to poor cell adhesion and proliferation, hence it is blended with other synthetic /natural polymers.

Application

  • PCL loaded with antibiotics may be used to treat infections of the respiratory tract, like tuberculosis.
  • Investigations were carried out based upon phenotypic responses of human bone marrow mesenchymal cells (hBMSCs) for different ratio of chitosan/ polycaprolactone (PCL) blends.
  • PCL/biomedical ceramic materials have been studied for possible osteo tissue regeneration.
  • Action of PCL/graded insulin/beta-5 glycerophosphate concentrations on osteochondral tissue formation through adipose-derived stromal cell differentiation.
  • Other general uses include:extrusion aid, die lubricant, mold release, pigment and filler dispersion aid and polyester segments in urethanes and block polyesters.

Features and Benefits

Biodegradable polymer
Non-toxic, biodegradable in soil, broad miscibility, mechanical compatibility with many polymers and good adhesion to a broad spectrum of substrates.

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Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Hung-Jen Shao et al.
Journal of biomedical materials research. Part A, 100(12), 3344-3352 (2012-06-27)
The phenotypic responses of human bone marrow mesenchymal cells (hBMSCs) on different ratio of chitosan/polycaprolactone (PCL) blends were investigated in this study. The results showed that hBMSCs existed different morphology on chitosan/PCL blends due to the different adhesion characteristic of
Cevat Erisken et al.
Tissue engineering. Part A, 17(9-10), 1239-1252 (2010-12-30)
The ability to fabricate tissue engineering scaffolds containing systematic gradients in the distributions of stimulators provides additional means for the mimicking of the important gradients observed in native tissues. Here the concentration distributions of two bioactive agents were varied concomitantly
T Limongi et al.
Molecular neurobiology, 55(12), 8788-8798 (2018-03-31)
Biopolymers are increasingly employed for neuroscience applications as scaffolds to drive and promote neural regrowth, thanks to their ability to mediate the upload and subsequent release of active molecules and drugs. Synthetic degradable polymers are characterized by different responses ranging
Wendi Zhang et al.
Biomaterials, 34(27), 6495-6503 (2013-06-04)
Coating the polycation/DNA binary complexes with PEGylated polyanions can improve long-circulation and biocompatibility in vivo. However, it has been certificated PEG dilemma can reduces gene transfection efficiency because of inhibition in cellular uptake and endosomal escape. Herein, two PEGylated anionic
Wei Ching Low et al.
Biomaterials, 34(14), 3581-3590 (2013-02-19)
At present, the recovery prospect for patients with chronic neurodegenerative diseases or acute trauma in the central nervous system is sub-optimal. The controlled differentiation of neural stem/progenitor cells (NPCs) to functional neurons is a possible treatment strategy. In contrast to
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